Bahn RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN.
Thyroid. 2011 Apr 21. [PMID21510801)
Thyroid Antibody Positivity in the First Trimester of Pregnancy Is Associated with Negative Pregnancy Outcomes.
J Clin Endocrinol Metab. 2011 Mar 16
Thyroid antibody positivity during pregnancy has been associated with adverse outcomes including spontaneous miscarriage, recurrent miscarriage, and preterm delivery. The present study compared 14 maternal and neonatal adverse outcomes in 245 women who were euthyroid (TSH < 2.5 mIU/liter) and thyroid peroxidase positive in the first trimester to 3348 women who were euthyroid and thyroid peroxidase negative in the first trimester. The study consisted of 3593 women. The main result was an increase in very preterm delivery (<34 wk gestation at delivery) [4.5 vs. 1.8%; P = 0.003] and respiratory distress [3.3 vs. 1.2%; P = 0.005] in women who were thyroid antibody positive. The present study provides further evidence of an association between thyroid antibody positivity and very preterm delivery in euthyroid women. The association with respiratory distress should be considered preliminary.
More data documenting this striking and so far unexplained association.