Reading for this module should include Chapter 7 in Thyroid Disease Manager, or alternative sources. These could include chapters in Endocrinology, Edition III, comparable chapters in Endocrinology Edition IV , or appropriate chapters in "The Thyroid".
Anticipated study and testing time for this module is 3 hours. After reading the material, print out his page, complete the test, fill in required personal information, and send the page with payment to Center for Continuing Medical Education, 950 E 61st St., University of Chicago, Chicago, IL 60637., with payment of $45. After satisfactory completion of the examination, a certificate will be returned by mail.
| 1. Which of the following statements concerning T cells is true? | |
| A. All T cells express a T cell receptor composed of an a and b chain | |
| B. T cell receptor genes undergo somatic mutation to increase the diversity of antigens recognize | |
| C. T cell receptors recognize antigenic peptides of around 25 amino acids in size | |
| D. Specific V gene segments encoding the receptor rearrange with D and J segments to provide the unique recognition function of the receptor | |
| E. All T cells require costimulatory signals from B7.1 or B7.2 to undergo activation | |
| A. IL-2 | |
| B. TNF | |
| C. IL-4 | |
| D. g-IFN | |
| E. IL-1 | |
3. Which of the following statements concerning thyroglobulin as an autoantigen is true? |
|
| A. There are 4-6 major B cell epitopes | |
| B. Thyroglobulin antibodies fix complement | |
| C. Iodide content does not affect the antigenicity of thyroglobulin in animal models of thyroiditis | |
| D. There is sequence homology with the TSH-receptor | |
| E. It is a 670 kD molecule comprised of 4 identical subunits | |
| A. Na+/I- symporter | |
| B. DNA | |
| C. Acetylcholine receptor | |
| D. Thyroid peroxidase | |
| E. Megalin | |
| A. Block the receptor | |
| B. Displace 125I-TSH binding | |
| C. Bind to conformational epitopes | |
| D. Fix complement | |
| E. Stimulate the receptor | |
| A. BB/W rat | |
| B. Immunization of mice with fibroblasts transfected with TSH-receptor | |
| C. OS chicken | |
| D. Genetic immunization of mice with TSH-receptor cDNA | |
| E. NOD mouse | |
| A. Na+/I- symporter | |
| B. T4 | |
| C. Thyroid peroxidase | |
| D. TSH receptor | |
| E. Thyroglobulin | |
| A. HLA-DRB1*07 | |
| B. HLA-DQA*0501 | |
| C. HLA-DR4 | |
| D. HLA-DR3-linked haplotypes | |
| E. CTLA-4 | |
| A. Sjögren's syndrome | |
| B. Celiac disease | |
| C. Premature ovarian failure | |
| D. Autoimmune polyglandular syndrome type 1 | |
| E. Psoriasis | |
| A. HLA-DR-positive T cells increase in the circulation after methimazole treatment | |
| B. CD4+ T cells infiltrate the thyroid | |
| C. Changes in circulating T cell subsets are similar to those in other autoimmune diseases | |
| D. CD8+ T cells infiltrate the thyroid | |
| Answer Sheet | |||||
| Enter "True" or "False" in the appropriate boxes. | |||||
| A (True/False) | B (True/False) | C (True/False) | D (True/False) |
E (True/False) |
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