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Chapter 3

Thyroid Hormone Transport, Cellular Uptake, Metabolism, and Molecular Action

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Clinical summary
Thyroid hormone metabolism in humans
Type I iodothyronine deiodinase (D1)
Biochemistry
Pathophysiology
Type II iodothyronine deiodinase (D2)
Biochemistry
Pathophysiology
Type III iodothyronine deiodinase (D3)
Biochemistry
Pathophysiology
Importance of D3 during fetal development
Sulfation
Iodothyronine sulfotransferases
Deiodination of iodothyronine sulfates
Importance of thyroid hormone sulfation
Glucuronidation

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