Table of Contents

INTRODUCTION

BINDING OF THs TO NUCLEAR RECEPTORS

CLONING, STRUCTURE, AND EXPRESSION OF TH RECEPTORS

Cloning of TH receptors

Structure of TH receptors

Splicing variants of TH receptors

Tissue and developmental expression of TRs

TRANSCRIPTIONAL REGULATION BY TH RECEPTORS

TR binding to TH response elements (TREs)

Basal repression/Transcriptional corepressors

Transcriptional activation/Coactivators

Negative regulation by TRs

Nongenomic pathways regulated by TH

TH analogs, metabolites, and antagonists

SUMMARY

Acknowledgement