1. McIver B, Gorman CA 1997 Euthyroid sick syndrome: An overview. Thyroid 7:125-132

2.DeGroot, LJ. "Non-thyroidal illness syndrome" is functional central hypothyroidism, and if severe, hormone replacement is appropriate in light of present knowledge. J Endocrinol Invest 26 1163-1170 2003.

3..Stathatos, N; Wartofsky, L. The euthyroid sick syndrome: Is there a physiologic rationale for thyroid hormone treatment? J Endocrinol Invest 26 1174-1179 2003.

4. Hennemann G, Docter R, Krenning EP 1988 Causes and effects of the low T3 syndrome during caloric deprivation and non-thyroidal illness: an overview. Acta Med Kaust 15:42-45

5. Phillips RH, Valente WA, Caplan ES, Connor TB, Wiswell JG 1984 Circulating thyroid hormone changes in acute trauma: Prognostic implications for clinical outcome. J Trauma 24:116-119

6. Vardarli I, Schmidt R, Wdowinski JM, Teuber J, Schwedes U, Usadel KH 1987 The hypothalamo-hypophyseal thyroid axis, plasma protein concentrations and the hypophyseogonadal axis in low T3 syndrome following acute myocardial infarct. Klin Wochenschrift 65:129-133

7. Eber B, Schumacher M, Langsteger W, Zweiker R, Fruhwald FM, Pokan R, Gasser R, Eber O, Klein W 1995 Changes in thyroid hormone parameters after acute myocardial infarction. Cardiology 86:152-156

8. Holland FW, Brown PS, Weintraub BD, Clark RE 1991 Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome." Ann Thorac Surg 52:46-50

9. Vexiau P, Perez-Castiglioni P, Socie G, Devergie A, Toubert ME, Aractingi S, Gluckman E 1993 The 'euthyroid sick syndrome': Incidence, risk factors and prognostic value soon after allogeneic bone marrow transplantation. Br J Hematol 85:778-782

10. Harris ARC, Fang SL, Vagenakis AG, Braverman LE 1978 Effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the rat. Metabolism 27:1680-1690

11. Welle SL, Campbell RG 1986 Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment. Metabolism 35:289-291

12. Girvent M, Maestro S, Hernandez R, Carajol I, Monne J, Sancho JJ, Gubern JM, Sitges-Serra A. Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. Surgery 123:560-567, 1998.

13. Wartofsky L, Burman KD 1982 Alterations in thyroid function in patients with systemic illnesses: The "Euthyroid Sick Syndrome". Endocrine Rev 3:164-217

14. Kaptein EM 1997 Clinical relevance of thyroid hormone alterations in nonthyroidal illness. Thyroid International 4:22-25

15. Docter R, Krenning EP, de Jong M, Hennemann G 1993 The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol 39:499-518

16. Chopra IJ, Huang TS, Boado R, Solomon DH, Chua Teco GN 1987 Evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness: Studies using turpentine oil-injected rat. J Endocrinol Invest 10:559-564

17 Schilling JU, Zimmermann T, Albrecht S, Zwipp H, Saeger HD. 1999 Low T3 syndrome in multiple trauma patients ¿ a phenomenon or important pathogenetic factor? Medizinische Klinik 3:66-69.

18 Schulte C, Reinhardt W, Beelen D, Mann K, Schaefer U. 1998 Low T3-syndrome and nutritional status as prognostic factors in patients undergoing bone marrow transplantation. Bone Marrow Transplantation 22:1171-1178.

19 Girvent M, Maestro S, Hernandez R, et al. 1998 Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. Surgery 123:560-567.

20. Maldonado LS, Murata GH, Hershman JM, Braunstein GD. Do thyroid function tests independently predict survival in the critically ill? Thyroid 2:119, 1992

21. Vaughan GM, Mason AD, McManus WF, Pruitt BA 1985 Alterations of mental status and thyroid hormones after thermal injury. J Clin Endocrinol Metab 60:1221

22. De Marinis L, Mancini A, Masala R, Torlontano M, Sandric S, Barbarino A 1985 Evaluation of pituitary-thyroid axis response to acute myocardial infarction. J Endocrinol Invest 8:507

23. Surks MI, Hupart KH, Pan C, Shapiro LE 1988 Normal free thyroxine in critical nonthyroidal illnesses measured by ultrafiltration of undiluted serum and equilibrium dialysis. J Clin Endocrinol Metab 67:1031-1039

24. Melmed S, Geola FL, Reed AW, Pekary AE, Park J, Hershman JM 1982 A comparison of methods for assessing thyroid function in nonthyroidal illness. J Clin Endocrinol Metab 54:300-306

25. Kaptein EM, MacIntyre SS, Weiner JM, Spencer CA, Nicoloff JT 1981 Free thyroxine estimates in nonthyroidal illness: comparison of eight methods. J Clin Endocrinol Metab 52:1073-1077

26 Kantor, M., et al., Admission thyroid evaluation in very-low-birth-weight infants: association with death and severe intraventricular hemorrhage. Thyroid, 2003. 13: p. 965.

27. Chopra IJ, Solomon DH, Hepner GW, Morgenstein AA 1979 Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses. Ann Int Med 90:905-912

28. Bacci V, Schussler GC, Kaplan TB 1982 The relationship between serum triiodothyronine and thyrotropin during systemic illness. J Clin Endocrinol Metab 54:1229-1235

29. Sapin R, Schlienger JL, Kaltenbach G, Gasser F, Christofides N, Roul G, Gervais A, Petitjean P, Chambron J 1995 Determination of free triiodothyronine by six different methods in patients with nonthyroidal illness and in patients treated with amiodarone. Ann Clin Biochem 32:314-324.

30. Chopra IJ, Taing P, Mikus L 1996 Direct determination of free triiodothyronine (T3) in undiluted serum by equilibrium dialysis/radioimmunoassay. Thyroid 6:255-259

31. Chopra IJ 1998 Simultaneous measurement of free thyroxine and free 3,5,3'-triiodothyronine in undiluted serum by direct equilibrium dialysis/radioimmunoassay: evidence that free triiodothyronine and free thyroxine are normal in many patients with the low triiodothyronine syndrome. 32

31a. Peeters RP, Wouters PJ, Kaptein E, van Toor H, Visser TJ, Van den Berghe G. : J Clin Endocrinol Metab. 2003 Jul;88(7):3202-11. Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients.

32. Klemperer JD, Klein I, Gomez M, Helm RE, Ojamaa K, Thomas SJ, Isom OW, Kreiger K 1995 Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med 333:1522-1527

33. Osburne RC, Myers EA, Rodbard D, Burman KD, Georges LP, O'Brian JT 1983 Adaptation to hypocaloric feeding: Physiologic significance of the fall in T3. Metabolism 32:9-13.

34 Afandi B, Schussler GC, Arafeh A-H, Boutros A, Yap MG, Finkelstein A. Selective consumption of thyroxine-binding globulin during cardiac bypass surgery. Metabolism 49:270-274, 2000

35 Jirasakuldech B, Schussler GC, Yap MG, Drew H, Josephson A, Michl J. A characteristic serpin cleavage product of thyroxine-binding globulin appears in sepsis sera. J Clin Endocrinol Metab 85:3996-3999, 2000.

35a. den Brinker M, Joosten KF, Visser TJ, Hop WC, de Rijke YB, Hazelzet JA, Boonstra VH, Hokken-Koelega AC : J Clin Endocrinol Metab. 2005 Oct;90(10):5613-20.

36. Uchimura H, Nagataki S, Tabuchi T, Mizuno M, Ingbar SH 1976 Measurements of free thyroxine: Comparison of percent of free thyroxine in diluted and undiluted sera. J Clin Endocrinol Metab 42:561-566

37. Nelson JC, Weiss RM 1985 The effect of serum dilution on free thyroxine concentration in the low T4 syndrome of nonthyroidal illness. J Clin Endocrinol Metab 61:239-246

38 Wang R, Nelson JC, Weiss RM, Wilcox RB. 2000 Accuracy of free thyroxine measurements across natural ranges of thyroxine binding to serum proteins. Thyroid 10:31-39.

39. Kaptein EM 1996 Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocrine Rev 17:45-63

40. Liewendahl K, Helenius T, Naveri H, Tikkanen H 1992 Fatty acid-induced increase in serum dialyzable free thyroxine after physical exercise: implication for nonthyroidal illness. J Clin Endocrinol Metab 74:1361-1365

41. Mendel CM, Frost PH, Cavalieri RR 1986 Effect of free fatty acids on the concentration of free thyroxine in human serum: the role of albumin. J Clin Endocrinol Metab 63:1394-1399

42. Jaume JC, Mendel CM, Frost PH, Greenspan FS, Laughton CW 1996 Extremely low doses of heparin release lipase activity into the plasma and can th

43. Wang Y-S, Hershman JM, Pekary AE 1985 Improved ultarfiltration method for simultaneous measurement of free thyroxine and free triiodothyronine in serum. Clin Chem 31:517-522

44. Mendel CM, Laughton CW, McMahon FA, Cavalieri RR 1991 Inability to detect an inhibitor of thyroxine-serum protein binding in sera from patients with nonthyroidal illness. Metabolism 40:491-502

45. Chopra IJ, Huang T-S, Beredo A, Solomon DH, Chua Teco GN, Mead JF 1985 Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in sera of patients with nonthyroidal illnesses. J Clin Endocrinol Metab 60:666

46 Wang R, Nelson JC, Wilcox RB. 1998 Salsalate administration ¿ a potential pharmacological model of the sick euthyroid syndrome. J Clin Endocrinol Metab 83:3095-3099.

47. Csako G, Zweig MH, Benson C, Ruddel M 1987 On the albumin-dependence of the measurement of free thyroxine. II. Patients with nonthyroidal illness. Clin Chem 33:87-92

48. Chopra IJ, Chua Teco GN, Mead JF, et al 1985 Relationship between serum free fatty acids and thyroid hormone binding inhibitor in nonthyroid illnesses. J Clin Endocrinol Metab 60:980-984

49. Brent GA, Hershman JM 1986 Thyroxine therapy in patients with severe nonthyroidal illnesses and lower serum thyroxine concentration. J Clin Endocrinol Metab 63:1-8

50. Chopra IJ 1996 Nonthyroidal illness syndrome or euthyroid sick syndrome? Endocrine Prac 2:45-52

51. Franklyn JA, Black EG, Betteridge J, Sheppard MC 1994 Comparison of second and third generation methods for measurement of serum thyrotropin in patients with overt hyperthyroidism, patients receiving thyroxine therapy, and those with nonthyroidal illness. J Clin Endocrinol Metab 78:1368-1371

52. Vierhapper H, Laggner A, Waldhausl W, Grubeck-Loebenstein B, Kleinberger G 1982 Impaired secretion of TSH in critically ill patients with 'low T4-syndrome'. Acta Endocrinol 101:542-549

53. Faber J, Kirkegaard C, Rasmussen B, Westh H, Busch-Sorensen M, Jensen IW 1987 Pituitary-thyroid axis in critical illness. J Clin Endocrinol Metab 65:315-320

54. Arem R, Deppe S 1990 Fatal nonthyroidal illness may impair nocturnal thyrotropin levels. Am J Med 88:258-262

55. Lee H-Y, Suhl J, Pekary AE, Hershman JM 1987 Secretion of thyrotropin with reduced concanavalin-A-binding activity in patients with severe nonthyroid illness. J Clin Endocrinol Metab 65:942

55.6. Thijssen-Timmer DC, Peeters RP, Wouters P, Weekers F, Visser TJ, Fliers E, Wiersinga WM, Bakker O, Berghe GV. Thyroid hormone receptor isoform expression in livers of critically ill patients. Thyroid. 2007 Feb;17(2):105-12.

56. Spratt DI, Bigos ST, Beitins I, Cox P, Longcope C, Orav J 1992 Both hyper- and hypogonadotropic hypogonadism occur transiently in acute illness: Bio- and immunoactive gonadotropins. J Clin Endocrinol Metab 75:1562-1570

57. Spratt DI, Cox P, Orav J, Moloney J, Bigos T 1993 Reproductive axis suppression in acute illness is related to disease severity. J Clin Endocrinol Metab 76:1548-155458 Van den Berghe G, Weekers F, Baxter RC, Wouters P, Iranmanesh A, Bouillon R, Veldhuis JD. Five-day pulsatile gonadotropin-releasing hormone administration unveils combined hypothalamic-pituitary-gonadal defects underlying profound hypoandrogenism in men with prolonged critical illness. J Clin Endocrinol Metab 86:3217-3226, 2001.

59. Kaptein EM, Grieb DA, Spencer CA, Wheeler WS, Nicoloff JT 1981 Thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses. J Clin Endocrinol Metab 53:764-771

60. Kaptein EM, Robinson WJ, Grieb DA, Nicoloff JT 1982 Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute nonthyroidal illnesses. A noncompartmental analysis. J Clin Invest 69:526-535

61. Lim VS, Fang VS, Katz AI, Refetoff S 1977 Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover 652. Lim C-F, Docter R, Visser TJ, Krenning EP, Bernard B, van Toor H, de Jong M, Hennemann G 1993 Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: Effects of bilirubin and nonesterified fatty acids. J Clin Endocrinol Metab 76:1165-1172

62. Berger MM, Lemarchand-Beraud T, Cavadini C, Chiolero R 1996 Relations between the selenium status and the low T3 syndrome after major trauma. Intensive Care Med 22:575-581

63. Vos RA, de Jong M, Bernard BF, Docter R, Krenning EP, Hennemann G 1995 Impaired thyroxine and 3,5,3'-triiodothyronine handling by rat hepatocytes in the presence of serum of patients with nonthyroidal illness. J Clin Endocrinol Metab 80:2364-2370

64. Lim C-F, Docter R, Krenning EP, van Toor H, Bernard B, de Jong M, Hennemann G 1994 Transport of thyroxine into cultured hepatocytes: effects of mild nonthyroidal illness and calorie restriction in obese subjects. Clinical Endocrinol 40:79-85

65. Sarne DH, Refetoff S 1985 Measurement of thyroxine uptake from serum by cultured human hepatocytes as an index of thyroid status: Reduced thyroxine uptake from serum of patients with nonthyroidal illness. J Clin Endocrinol Metab 61:1046-1052

66 Krenning, D., et al., Decreased transport of thyroxine (T4), 3, 3', 5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs. FEBS Lett, 1982. 140: p. 229-233.

67 Peeters, R., et al., Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. J Clin Endocrinol Metab, 2003. 88: p. 3202-3211

68. Arem R, Wiener GJ, Kaplan SG, Kim H-S, Reichlin S, Kaplan MM 1993 Reduced tissue thyroid hormone levels in fatal illness. Metabolism 42:1102-1108

68a. Peeters RP, van der Geyten S, Wouters PJ, Darras VM, van Toor H, Kaptein E,Visser TJ, Van den Berghe G.: J Clin Endocrinol Metab. 2005 Dec;90(12):6498-507. Epub 2005 Sep 20. Tissue thyroid hormone levels in critical illness.

69 d¿Amati G, di Gioia CRT, Mentuccia D, Pistilli D, Proietti-Pannunzi L, Miraldi F, Gallo P, Celi FS. Increased expression of thyroid hormone receptor isoforms in end-stage human congestive heart failure. J Clin Endocrinol Metab 86:2080-2084, 2001.

70 Sanchez, B. and T. Jolin, Triiodothyronine-receptor complex in rat brain: effects of thyroidectomy, fasting, food restriction, and diabetes. Endocrinology, 1991. 129: p. 361-367.

71 Beigneux, A., et al., Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver. Am J Physiol Endocrinol Metab, 2003. 284: p. E228-E236.

72. Brent GA, Hershman JM, Reed AW, Sastre A, Lieberman J 1986 Serum angiotensin converting enzyme in severe nonthyroidal illness associated with low serum thyroxine concentration. Ann Intern Med 100:680-683

73. Seppel T, Becker A, Lippert F, Schlaghecke R 1996 Serum sex hormone-binding globulin and osteocalcin in systemic nonthyroidal illness associated with low thyroid hormone concentrations. J Clin Endocrinol Metab 81:1663-1665

73a. Chapital AD, Hendrick SR, Lloyd L, Pieper D.Am Surg. 2001 Mar;67(3):253-5

74. Kaplan MM 1979 Subcellular alterations causing reduced hepatic thyroxine-5'-monodeiodinase activity in fasted rats. Endocrinology 104:58-64

75 Berger MM, Reymond MJ, Shenkin A, Rey F, Wardle C, Cayeux C, Schindler C, Chiolero RL. Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Med 27:91-100,

76 Afandi B, Schussler GC, Arafeh AH, Boutros A, Yap MG, Finkelstein A. Selective consumption of thyroxine-binding globulin during cardiac bypass surgery. Metab Clin Exper 49:270-274, 2000. 2001.

77. Blake NG, Eckland JA, Foster OJF, Lightman SL 1991 Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation. Endocrinology 129:2714-2718

78. Fliers E, Guldenaar SEF, Wiersinga WM, Swaab DF 1997 Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J Clin Endocrinol Metab 82:4032-4036

79. Van den Berghe G, De Zegher F, Baxter RC, Veldhuis JD, Wouters P, Schetz M, Verwaest C, Van der Vorst E, Lauwers P, Bouillon R, Bowers CY 1998 Neuroendocrinology of prolonged critical illness: Effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues. J Clin Endocrinol Metab 83:309-319

80. Nicoloff JT, Fisher DA, Appleman MD Jr 1970 The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest 49:1922

81. Brabant G, Brabant A, Ranft U 1987 Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration. J Clin Endocrinol Metab 65:83

82. Benker G, Raida M, Olbricht T, Wagner R, Reinhardt W, Reinwein D 1990 TSH secretion in Cushing's syndrome: relation to glucocorticoid excess, diabetes, goiter, and the 'sick euthyroid syndrome'. Clin Endocrinol 33:777-786

83. Bianco AC, Nunes MT, Hell NS, Maciel RMB 1987 The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats. Endocrinology 120:1033-1038

84. Lim VS, Passo C, Murata Y, Ferrari E, Nakamura H, Refetoff S 1984 Reduced triiodothyronine content in liver but not pituitary of the uremic rat model: Demonstration of changes compatible with thyroid hormone deficiency in liver only. Endocrinology 114:280-286

85. Beale E, Srivastava P, Liang H, LoPresti J, Spencer C, Nicoloff J 1997 Triiodothyroacetic acid (T3AC) -- Is it an intracellular autocrine acting form of thyroid hormone? Abstract No. OR1-1 presented at the 79th Annual Meeting of the Endocrine Society, Minneapolis, MN

86 Van den Berghe, G., F. de Zegher, and R. Bouillon, Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab, 1998. 83: p. 1827-1834.

87 Van den Berghe, G., et al., Intensive insulin therapy in critically ill patients. N Engl J Med, 2001. 345: p. 1359-1367.

87a. . Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ.: Neurology. 2005 Apr 26;64(8):1348-53. Insulin therapy protects the central and peripheral nervous system of intensive care patients.

87b. Weekers F, Giulietti AP, Michalaki M, Coopmans W, Van Herck E, Mathieu C, Van

den Berghe G.: Endocrinology. 2003 Dec;144(12):5329-38. Epub 2003 Aug 28. Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness.

88 Monig H, Arendt T, Meyer M, Kloehn S, Bewig B. Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases¿implications for the euthyroid sick syndrome. Intensive Care Medicine 25:1402-1406, 1999.

89. Hermus ARMM, Sweep CGJ, van der Meer MJM, Ross HA, Smals AGH, Benraad TJ, Kloppenborg PWC 1992 Continuous infusion of interleukin-1 induces a nonthyroidal illness syndrome in the rat. Endocrinology 131:2139-2146

90. Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, Van Der Meer JWM, Endres S, Lonnemann G, Corsetti J, Chernow B, Wilmore DW, Wolff SM, Burke JF, Dinarello CA 1990 Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 161:79-84

91. van der Poll T, Van Zee KJ, Endert E, Coyle SM, Stiles DM, Pribble JP, Catalano MA, Moldawer LL, Lowry SF 1995 Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. J Clin Endocrinol Metab 80:1341-1346

92 de Metz J, Romijn JA, Endert E, Corssmit EP, Sauerwein HP. Administration of interferon-g in healthy subjects does not modulate thyroid hormone metabolism. Thyroid 10:87-91, 2000.

93. Chopra IJ, Sakane S, Chua Teco GN 1991 A study of the serum concentration of tumor necrosis factor- in thyroidal and nonthyroidal illnesses. J Clin Endocrinol Metab 72:1113-1116

94 Van der Poll T, Endert E, Coyle SM, Agosti JM, Lowry SF. 1999 Neutralization of TNF does not influence endotoxin induced changes in thyroid hormone metabolism in humans. Amer J Physiol. 276:R357-362

95. van der Poll T, Romijn JA, Wiersinga WM, Saurwein HP 1990 Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. J Clin Endocrinol Metab 71:1567-1572

96 Nagaya T, Fujieda M, Otsuka G, Yang JP, Okamoto T, Seo H. A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome.J Clin Invest. 2000 Aug;106(3):393-402

97. Bartalena L, Brogioni S, Grasso L, Velluzzi F, Martino E 1994 Relationship of the increased serum interleukin-6 concentration to changes of thyroid function in nonthyroidal illness. J Endocrinol Invest 17:269-274

98. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM 1993 Association between serum interleukin-6 and serum 3,5,3'-triiodothyronine in nonthyroidal illness. J Clin Endocrinol Metab 77:1695-1699

99. Stouthard JML, van der Poll T, Endert E, Bakker PJM, Veenhof CHN, Sauerwein HP, Romijn JA 1994 Effects of acute and chronic Interleukin-6 administration on thyroid hormone metabolism in humans. J Clin Endocrinol Metab 79:1342-1346

100. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM 1997 Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice. J Endocrinol 153:115-122

101. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM 1996 Relationship between serum 3,5,3'-triiodothyronine and serum Interleukin-8, Interleukin-10 or Interferon-gamma in patients with nonthyroidal illness. J Endocrinol Invest 19:480-483

102 De Metz J, Romijn JA, Endert E, Corssmit EPM, Sauerwein HP. 2000 Administration of Interferon-g in healthy subjects does not modulate thyroid hormone metabolism. Thyroid 10:87-91.

103 Michalaki M, Vagenakis AG, Makri M, Kalfarentzos F, Kyriazopoulou V. Dissociation of the early decline in serum T3 concentration and serum IL-6 rise and TNFa in nonthyroidal illnss syndrome induced by abdominal surgery. J Clin Endocrinol Metab 86:4198-4205, 2001

104. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM 1995 Soluble cytokine receptors and the low 3,5,3'-triiodothyronine syndrome in patients with nonthyroidal disease. J Clin Endocrinol Metab 80:971-976

105 Schultes, B., et al., Acute and prolonged effects of insulin-induced hypoglycemia on the pituitary-thyroid axis in humans. Metabolism, 2002. 51: p. 1370-1374.

106 Pereira, D. and R. Procianoy, Effect of perinatal asphyxia on thyroid-stimulating hormone and thyroid hormone levels. Acta Pediatr, 2003. 92: p. 339-345.

107. Custro N, Scafidi V, Costanzo G, Calanni S 1989 Role of high blood glucagon in the reduction of serum levels of triiodothyronine in severe nonthyroid diseases. Minerva Endocrinol 14:221-226

108. Van den Berghe G, de Zegher F, Lauwers P 1994 Dopamine and the sick euthyroid syndrome in critical illness. Clin Endocrinol 41:731-737

109. Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 138:2569-2576, 1997.

110. Legradi G, Emerson CH, Ahima RS, Rand WM, Flier JS, Lechan RM 1998 Arcuate nucleus ablation prevents fasting-induced suppression of proTRH mRNA in the hypothalamic paraventricular nucleus. Neuroendocrinology 68:89-97

111. . Flier JS, Harris M, Hollenberg AN. Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest 105:859-861, 2000

112 Van den Berghe, G., et al., Neuroendocrinology of prolonged critical illness; effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues. J Clin Endocrinol Metab, 1998. 83: p. 309-319.

113 Bornstein, S.R., et al., Leptin levels are elevated despite low thyroid hormone levels in the "euthyroid sick" syndrome. J Clin Endocrinol Metab, 1997. 82(12): p. 4278-9.

114 Vesely DL, San Miguel GI, Hassan I, Gower WR, Schocken DD. Atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of total and free T4 and free T3 with reciprocal increase in TSH. J Clin Endocrinol Metab 86:5438-5442, 2001.

114. Kidess AI, Caplan RH, Reynertson RH, Wickus GG, Goodnough DE 1993 Transient corticotropin deficiency in critical illness. Mayo Clin Proc 68:435-441

115. Merry WH, Caplan RH, Wickus GG, Reynertson RH, Kisken WA, Cogbill TH, Landercasper J 1994 Acute adrenal failure due to transient corticotropin deficiency in postoperative patients. Surgery 116:1095-1100

116. Lambert SWJ, Bruining HA, DeLong FH 1997 Corticosteroid therapy in severe illness. N Engl J Med 337:1285-1292

117. Becker RA, Vaughan GM, Ziegler MG, Seraile LG, Goldfarb W, Mansour EH, McManus WF, Pruitt BA, Mason AD 1982 Hypermetabolic low triiodothyronine syndrome of burn injury. Critical Care Med 10:870-875

118 Siegel, N., et al., Beneficial effect of thyroxine on recovery from toxic acute renal failure. Kidney International, 1984. 25: p. 906-911.

119. Acker CG, Singh AR, Flick RP, Bernardini J, Greenberg A, Johnson JP. A trial of thyroxine in acute renal failure. Kidney International 57:293-298, 2000.

120 Acker CG, Flick R, Shapiro R, Scantlebury VP, Jordan ML, Vivas C, Greenberg A, Johnson JP. Thyroid hormone in the treatment of post-transplant acute tubular necrosis (ATN). Am J Transplant 2:57-61, 2002.

121 Little Js 1985 Effect of thyroid hormone on survival after bacterial infection. Endocrinology 117:1431-1435.

122. Chopra IJ, Huang TS, Boado R, Solomon DH, Chua Teco GN 1987 Evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness: studies using turpentine oil-injected rat. J Endocrinol Invest 10:559

123. Hsu R-B, Huang T-S, Chen Y-S, Chu S-H 1995 Effect of triiodothyronine administration in experimental myocardial injury. J Endocrinol Invest 18:702-709

124 Katzeff HL, Powell SR, Ojamaa K. 1997 Alterations in cardiac contractility and gene expression during low T3 syndrome: prevention with T3. Amer J Physiol 273:E951-956.

125. Chapital AD, Hendrick SR, Lloyd L, Pieper D. The effects of triiodothyronine augmentation on antithrombin III levels in sepsis. Am Surg 67:253-255, 2001

126. Shigematsu H, Shatney CH 1988 The effect of triiodothyronine and reverse triiodothyronine on canine hemorrhagic shock. Nippon Geka Gakkai Zasshi 89:1587-1593

127. Facktor MA, Mayor GH, Nachreiner RF, D'Alecy LG 1993 Thyroid hormone loss and replacement during resuscitation from cardiac arrest in dogs. Resuscitation 26:141-162

128. Schoenberger W, Grimm W, Emmrich P, Gempp W 1979 Thyroid administration lowers mortality in premature infants. Lancet 2:1181

129. Novitzky, D., D. Cooper, and B. Reichart, Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation, 1987. 43: p. 852-855.

130. Novitzky, D., et al., Improved cardiac allograft function following triiodothyronine therapy to both donor and recipient. Transplantation, 1990. 49: p. 311-316

131 Goarin JP, Cohen S, Riou B, Jacquens Y, Guesde R, Le Bret F, Aurengo A, Coriat P. The effects of triiodothyronine on hemodynamic status and cardiac function in potential heart donors. Anesth Analg 83:41-47, 1996.

132 Hesch, R., et al., Treatment of dopamine-dependent shock with triiodothyronine. Endocr Res Commun, 1981. 8: p. 299-301.

133 Meyer, T., et al., Treatment of dopamine-dependent shock with triiodothyronine: preliminary results. Dtsch Med Wochenschr, 1979. 104: p. 1711-1714.

134. Dulchavsky, S., et al., Beneficial effects of thyroid hormone administration on metabolic and hemodynamic function in hemorrhagic shock. FASEB, 1990. J 4:A952.

135. Dulchavsky, S., et al., T3 preserves respiratory function in sepsis. J Trauma, 1991. 31: p. 753-759.

136 Dulchavsky, S., S. Hendrick, and S. Dutta, Pulmonary biophysical effects of triiodothyronine (T3) augmentation during sepsis-induced hypothyroidism. Trauma, 1993. 35: p. 104-109.

.137. Klemperer, J., et al., Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med, 1995. 333: p. 1522-1527.

138. Bennett-Guerro, E., et al., Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass graft surgery. A randomized, double-blind, placebo-controlled trial. Duke T3 Study Group. J Am Med Assoc, 1996. 275: p. 687-692.

139. Hamilton MA, Stevenson LW 1996 Thyroid hormone abnormalities in heart failure: possibilities for therapy. Thyroid 6:527-529

140 Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med 345:1223-1229, 2001.

141 Annane D, Sebille V, Charpentier C, Bollaert P-E, Francois B, Korach J-M, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. J Amer Med Assn 288:862-871, 2002.

142 Hamrahian AH, Oseni TS, Arafah BM. Measurements of serum free cortisol in critically ill patients.N Engl J Med. 2004 Apr 15;350(16):1629-38

143 Van den Berghe G, Weekers F, Baxter RC, Wouters P, Iranmanesh A, Bouillon R, Veldhuis JD. Five-day pulsatile gonadotropin-releasing hormone administration unveils combined hypothalamic-pituitary-gonadal defects underlying profound hypoandrogenism in men with prolonged critical illness. J Clin Endocrinol Metab 86:3217-3226, 2001

144 Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, Hinds CJ. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med:341:785-792, 1999.

145. Weekers F, Michalaki M, Coopmans W, Van Herck E, Veldhuis JD, Darras VM, Van den Berghe G Endocrine and metabolic effects of growth hormone (GH) compared with GH-releasing peptide, thyrotropin-releasing hormone, and insulin infusion in a rabbit model of prolonged critical illness.Endocrinology. 2004 Jan;145(1):205-13.

145a. Van den Berghe G, Baxter RC, Weekers F, Wouters P, Bowers CY, Iranmanesh A,Veldhuis JD, Bouillon R: Clin Endocrinol (Oxf). 2002 May;56(5):655-69. The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH tomen with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone

145b. .Mesotten D, Wouters PJ, Peeters RP, Hardman KV, Holly JM, Baxter RC, Van den Berghe G.: J Clin Endocrinol Metab. 2004 Jul;89(7):3105-13. Regulation of the somatotropic axis by intensive insulin therapy during protracted critical illness.