1. Janeway CA, Carding S, Jones B, Murray J, Portoles P, Rasmussen R, Rojo J, Saizawa K, West J, Bottomly K. CD4 ⁺T cells: specificity and function. Immunol Rev 101:39-80, 1988.

2.Kronenberg M, Siu G, Hood LE, Shastri N. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Ann Rev Immunol 4:529, 1986.

3.Isakov N. Cell activation and signal initiation. Immunol Today 9:251-253, 1988.

4.Panzara MA, Oksenberg JR, Steinman L. The polymerase chain reaction for detection of T-cell antigen receptor expression. Current Opinion in Immunol 4:205-210, 1992.

5.Germain RN. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation. Cell 76:287-299, 1994.

6. Gor DO, Rose NR, Greenspan NS. Th1-Th2: a Procrustean paradigm. Nature Immunol 4:503-505, 2004.

7.Von Andrian UH, Mackay CR. T-cell function and migration. New Engl J Med 343:1020-1034, 2000.

8.Matsuda F, Honjo T. Organization of the human immunoglobulin heavy chain locus. Adv Immunol 62:1-29, 1996.

9.Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 392:245-252, 1998.

10Yadav D, Judkowski V, Flodstrom-Tullberg M, Sterling L, Redmond WL, Sherman L, Sarvetnick N. B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. J Immunol 173:3631-3939, 2004.

11.Sansom DN, Manzotti CN, Zheng Y. What’s the difference between CD80 and CD86? Trends Immunol 24:314-319, 2003.

12.Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends in Immunol 23:445-449, 2002.

13.Drakesmith H, Chain B, Beverley P. How can dendritic cells cause autoimmune disease? Immunol Today 21:215-217, 2000.

14.Doyle HA, Mamula MJ. Post-translational protein modifications in antigen recognition and autoimmunity. Trends in Immunol 22:443-449, 2001.

15.Goodnow CC. Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci USA 93:2264-2271, 1996.

16.Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of the immune response. Ann Rev Immunol 20:29-53, 2002.

17.Gonzalo J-A, Delaney T, Cocoran J, Goodearl A, Gutierrez-Ramos JC, Coyle AJ. The related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation. J Immunol 166:1-5, 2001.

18.Pérez-Melgosa M, Hollenbaugh D, Wilson CB. CD40 ligand is a limiting factor in the humoral response to T cell-dependent antigens. J Immunol 163:1123-1127, 1999.

19. Duddy ME, Alter A, Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol 172:3422-3427, 2004.

20.Swain SL, Dutton RW. Consequences of the direct interaction of helper T cells with B cells presenting antigen. Immunol Rev 99:263-280, 1987.

.

20a. El Fassi D, Nielsen CH, Bonnema SJ, Hasselbalch HC, Hegedüs L.B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study J Clin Endocrinol Metab. 92:1769-72, 2007.

21Deeths MJ, Mescher MF. ICAM-1 and B7-1 provide similar but distinct costimulation for CD8 ⁺T cells, while CD4 ⁺T cells are poorly costimulated by ICAM-1. Eur J Immunol 29:45-53, 1999.

22.Sepulveda H, Cerwenka A, Morgan T, Dutton RW. CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation. J Immunol 163:1133-1142, 1999.

23.Trembleau S, Germann T, Gately MK, Adorini L. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today 16:383-386, 1995.

24.Batchelor JR, Lombardi G, Lechler RI. Speculations of the specificity of suppression. Immunol Today 10:37-40, 1989.

25. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nature Immunol 6: 338 – 344, 2005.

25a. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 8:345-50, 2007.

26 Sakaguchi S. Naturally arising Foxp3-expressing CD25 ⁺CD4 ⁺regulatory T cells in immunological tolerance to self and non-self. Nature Immunol 6: 345-352, 2005.

27.Fehervari Z, Yamaguchi T, Sakaguchi S. The dichotomous role of IL-2: tolerance versus immunity. Trends in Immunol 27: 109-11, 2006.

28.Raams LS, Smith J, Rustin MH, Salmon M, Poulter LW, Akbar AN. Human anergic/suppressive CD4 ⁺CD25 ⁺T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 31:1122-1131, 2001.

29.Powrie F, Maloy KJ. Regulating the regulators. Science 299:1030-1031, 2003.

30.Cozzo C, Larkin III J, Caton AJ. Cutting Edge:Self-peptides drive peripheral expansion of CD4 ⁺CD25 ⁺regulatory T cells1. J Immunol 171:5678-5682, 2003.

31.Jiang H, Chess L. Regulation of immune responses by T cells. New Engl J Med 354: 1166-1176, 2006.

32.Bach J-F. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347:911-920, 2002.

33.Perussia B, Loza MJ. Linear ‘2-0-1’ lymphocyte development: hypotheses on cellular bases for immunity. Trends Immunol. 24:235-241, 2003.

34.Venanzi ES, Benoist C, Mathis D. Good riddance: thyrmocyte clonal deletion prevents autoimmunity. Current Opin Immunol 16:197-22, 2004.

35. Kuroda N, Mitani T, Takeda N, et al. Development of autoimmunity against transcriptonally unrepressed target antigen in the thyrmus of Aire –deficient mice. J Immunol 174: 1862- 1870, 2005.

36.Nelson BH. IL-2, regulatory T cells, and tolerance. J Immunol 172:3938-3988, 2004.

37.Danke NA, Koelle DM, Yee C, Beheray S, Kwok WW. Autoreactive T cells in healthy individuals. J Immunol 172: 5967-5972, 2004.

38.De Maria R, Testi R. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunol Today 19:121-125, 1998.

39.Schwartz RS. Diversity of the immune repertoire and immunoregulation. N Engl J Med 348:1017-1026, 2003.

39a. Manetti L, Lupi I, Morselli LL, Albertini S, Cosottini M, Grasso L, Genovesi M, Pinna G, Mariotti S, Bogazzi F, Bartalena L, Martino E.

Prevalence and functional significance of antipituitary antibodies in patients with autoimmune and non-autoimmune thyroid diseases.

J Clin Endocrinol Metab.92:2176-81, 2007.

40.Shimojo N, Saito K, Kohno Y, Sasaki N, Tarutani O, Nakajima H. Antigenic determinants on thyroglobulin: comparison of the reactivities of different thyroglobulin preparations with serum antibodies and T cells of patients with chronic thyroiditis. J Clin Endocrinol Metab 66:689-695, 1988.

41.McLachlan SM, Rapoport B. Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies? Thyroid 14:510-520, 2004.

42.Vali M, Rose NR, Caturegli P. Thyroglobulin as autoantigen: Structure-function relationships. Rev Endocr Met Dis 1:69-77, 2000.

43.Lisi S, Marino M, Pinchera A, Mazzi B, Di Cosmo C, Sellari-Franceschini S, Chiovato L. Thyroglobulin in orbital tissues from patients with thyroid-associated ophthalmopathy: predominant localization in fibroadipose tissue. Thyroid 12:351-360, 2002.

44.Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G: Cloning, sequencing, and expression of the human thyrotropin (TSH) receptor: Evidence for binding of autoantibodies. Biochem Biophys Res Commun 165:1250-1255, 1989.

45.Nagayama Y, Kaufman KD, Seto P, Rapoport B: Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 165:1184-1190, 1989.

46.Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM. The thyrotropin (TSH)-releasing hormone receptor: interaction with TSH and autoantibodies. Endocrine Rev 19: 673-716, 1998.

47.Sanders J, Jeffreys J, Depraetere H, Richards T, Evans M, Kiddie A, Brereton K, Groenen M, Oda Y, Furmaniak J, Rees Smith B. Thyroid-stimulating monoclonal antibodies. Thyroid 12:1043-1050, 2002.

48.Costagliola S, Franssen JDF, Bonomi M, Urizar E, Willnich M, Bergmann A, Vassart G. Generation of a mouse monoclonal TSH receptor antibody with stimulating activity. BBSRC 299:891-896, 2002.

49.Ando T, Latif R, Pritsker A, Moran T, Nagayama Y, Davies TF. A monoclonal thyroid-stimulating antibody. J Clin Invest 110:1667-1674, 2002.

50.Dissecting linear and conformational epitopes on the native thyrotropin receptor. Endocrinology 145:5185-5193, 2004.

51.Chazenbalk GD, Latrofa F, McLachlan SM, Rapoport B, Thyroid stimulation does not require antibodies with identical epitopes but does involve recognition of a critical conformation at the N terminus of the thyrotropin receptor A-subunit. J Clin Endcrinol Metab 89:1788-1793, 2004.

52.Sanders J, Evans M, Premawardhana LDKE, Depraetere H, Jeffreys J, Richards T, Furmaniak J, Rees Smith B. Human monoclonal thyroid stimulating antibody. Lancet 362:126-28, 2003.

53.Chazenbalk GD, Pichurin P, Chen C-R, Latrofa F, Johnstone AP, McLachlan SM, Rapoport B. Thyroid-stimulating autoantibodies in Graves’ disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. J Clin Invest 110:209-217, 2002.

54.Chen C-R, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM. The thyrotropin receptor autoantigen in Graves’ disease is the culprit as well as the victim. J Clin Invest 111:1897-1904, 2003.

55.Molteni M, Zulian C, Scrofani S, Della Bella S, Bonara P, Kohn LD, Scorza R. High frequency of T-cell lines responsive to immunodominant epitopes of thyrotropin receptor in healthy subjects. Thyroid 8:241-245, 1998.

56. Inaba H, Martin W, De Groot AS, Qin S, De Groot LJ.Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves' disease. J Clin Endocrinol Metab 91:2286-94, 2006.

57.Ludgate M, Baker G. Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease. Clin Exp Immunol 127:193-198, 2002.

57a. Zhang L, Baker G, Janus D, Paddon CA, Fuhrer D, Ludgate M. Biological effects of thyrotropin receptor activation on human orbital preadipocytes. Invest Ophthalmol Vis Sci.47:5197-203, 2006.

57b. Douglas RS, Gianoukakis AG, Kamat S, Smith TJ.Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. J Immunol. 178:3281-7, 2007.

.

58.McLachlan SM, Rapoport B. The molecular biology of thyroid peroxidase: Cloning, expression, and role as autoantigen in autoimmune thyroid disease. Endocrine Rev 13:192-206, 1992.

59.Portmann L, Hamada N, Heinrich G, DeGroot LJ. Antithyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with anti-microsomal antibody. J Clin Endocrinol Metab 61:1001-1003, 1985.

60. Czarnocka B, Ruf J, Ferrand M, Carayon P, Lissitzky S. Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS Letters 190:147-152, 1985.

61.Libert F, Ruel J, Ludgate M, Swillens S, Alexander N, Vassart G, Dinsart C: Thyroperoxidase, an autoantigen with a mosaic structure made of nuclear and mitochondrial gene modules. EMBO J, 6:4193-4196, 1987.

62. Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayama T, Ohtaki S: Human thyroid peroxidase: Complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad Sci USA 84:5555-5559, 1987.

63. Magnusson RP, Chazenbalk GD, Gestautas J, Seto P, Filetti S, DeGroot, LJ, Rapoport B. Molecular cloning of the complementary deoxyribonucleic acid for human thyroid peroxidase. Molecul Endocrinol 1:856-861, 1987.

64.Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayama T, Ohtaki S. Human thyroid peroxidase: Complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad Sci USA 84:5555-5559, 1987.

65.McIntosh RS, Watson P MS, Weetman AP. Somatic hypermutation in autoimmune thyroid disease. Immunol Rev 162:219-231, 1998.

66.Hobby P, Gardas A, Radomski R, McGregor AM, Banga JP, Sutton BJ. Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase. Endocrinology 141:2018-2026, 2000.

67. Dubska M, Banga JP, Plochocka D, Hoser G, Kemp EH, Sutton BJ, Gardas A, Gora M.Structural insights into autoreactive determinants in thyroid peroxidase composed of discontinuous and multiple key contact amino acid residues contributing to epitopes recognized by patients' autoantibodies. Endocrinology 147: 5995-6003, 2006.

68.Jaume JC, Guo J, Pauls DL, Zakarija M, McKenzie JM, Egeland JA, Burek CL, Rose NR, Hoffman WH, Rapoport B, McLachlan SM. Evidence for genetic transmission of thyroid peroxidase autoantibody epitopic “fingerprints”. J Clin Endocrinol Metab 84: 1424-1431, 1999.

69.Tandon N, Freeman M, Weetman AP: T cell responses to synthetic thyroid peroxidase peptides in autoimmune thyroid disease. Clin Exp Immunol 86:56-60, 1991.

70.Fisfalen M-E, Soliman M, Okamoto Y, Soltani K, DeGroot LJ. Proliferative responses of T-cells to thyroid antigens and synthetic thyroid peroxidase peptides in autoimmune thyroid disease. J Clin Endocrinol Metab 80:1597-1604, 1995.

71.Khoury EL, Hammond L, Bottazzo GF, Doniach D. Presence of the organ-specific "microsomal" autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity. Clin Exp Immunol 45:316-328, 1981.

72.Iwatani Y, Iitaka M, Gerstein HC, Row VV, Volpe R. Separate induction of MHC and thyroid microsomal antigen (McAg) expression on thyroid cell monolayers: enhancement of lectin-induced McAg expression by interferon-γ. J Clin Endocrinol Metab 64:1302, 1987.

73.Kohno Y, Naito N, Hiyama Y, Shimojo N, Suzuki N, Tarutani O, Niimi H, Nakajima H, Hosoya T. Thyroglobulin and thyroid peroxidase share common epitopes recognized by autoantibodies in patients with chronic autoimmune thyroiditis. J Clin Endocrinol Metab 67:899-907, 1988.

74.Latrofa F, Pichurin P, Guo J, Rapoport B, McLachlan SM. Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies. J Clin Endocrinol Metab 88:371-378, 2003.

75.Raspé E, Costagliola S, Ruf J, Mariotti S, Dumont JE, Ludgate M. Identification of the thyroid Na+/I- cotransporter as a potential autoantigen in thyroid autoimmune disease. Europ J Endocrinol 132:399-405, 1995.

76.Endo T, Kogai T, Nakazato M, Saito T, Kaneshige M, Onaya T. Autoantibody against Na+/I- symporter in the sera of patients with autoimmune thyroid disease. Biochem Biophys Res Comm 224: 92-95, 1996.

77.Ajjan RA, Findlay C, Metcalfe RA, Watson PF, Crisp M, Ludgate M, Weetman AP. The modulation of the human sodium iodide symporter activity by Graves’ disease sera. J Clin Endocrinol Metab 83: 1217,1998.

78.Ajjan RA, Kemp EH, Waterman EA, Watson PF, Endo T, Onaya T, Weetman AP. Detection of binding and blocking autoantibodies to the human sodium-iodide symporter in patients with autoimmune thyroid disease. J Clin Endocrinol Metab 85:2020-2027, 2000.

79.Chin HS, Chin DKH, Morgenthaler NG, Vassart G, Costagliola S. Rarity of anti-Na+/I- transporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD). J Clin Endocrin Metab 85:3937-3940, 2000.

80.Ajjan RA, Kamaruddin NA, Crisp M, Watson PF, Ludgate M, Weetman AP. Regulation and tissue distribution of the human sodium iodide symporter gene. Clin Endocrinol 49: 517, 1998.

81.Benvenga S, Trimarchi F, Robbins J. Circulating thyroid hormone autoantibodies. J Endocrinol Invest 10:605, 1987.

82.Tachi J, Amino N, Iwatani Y, Tamaki H, Mori M, Aozasa M, Tanizawa O, Miyai K. Increase in antideoxyribonucleic acid antibody titer in postpartum aggravation of autoimmune thyroid disease. J Clin Endocrinol Metab 67:1049, 1988.

83.Katakura M, Yamada T, Aizawa T, Hiramatsu K, Yukimura Y, Ishihara M, Takasu N, Maruyama K, Kameko M, Kanai M, Kobayashi I. Presence of antideoxyribonucleic acid antibody in patients with hyperthyroidism of Graves' disease. J Clin Endocrinol Metab 64:405-408, 1987.

84.Marino M, Chiovato L, Friedlander JA, Latrofa F, Pinchera A, McCluskey RT. Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis. J Clin Endocrinol Metab 84: 2468-2474, 1999.

84a. Morgenthaler NG, Ho SC, Minich WB.Stimulating and blocking thyroid-stimulating hormone (TSH) receptor autoantibodies from patients with Graves' disease and autoimmune hypothyroidism have very similar concentration, TSH receptor affinity, and binding sites. J Clin Endocrinol Metab. 92:1058-65, 2007.

85.Chazenbalk GD, Wang Y, Guo J, Hutchison JS, Segal D, Jaume JC, McLachlan SM, Rapoport B. A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies. J Clin Endocrinol Metab 84: 702-710, 1999.

86.Weetman AP, Black CM, Cohen SB, Tomlinson R, Banga JP, Reimer CB. Affinity purification of IgG subclasses and the distribution of thyroid auto-antibody reactivity in Hashimoto’s thyroiditis. Scand J Immunol 30:73-82, 1989.

87.Williams RC, Marshall NJ, Kilpatrick K, Montano J, Brickell PM, Goodall M, Ealey PA, Shine B, Weetman AP, Craig RK. Kappa/lambda immunoglobulin distribution of Graves’ thyroid stimulating antibodies. Simultaneous analysis of Cλ gene polymorphisms. J Clin Invest 82:1306-1312, 1988.

88.Weetman AP, Yateman ME, Ealey PA, Black CM, Reimer CB, Williams RC Jr, Shine B, Marshall NJ. Thyroid-stimulating antibody activity between different immunoglobulin G subclasses. J Clin Invest 86:723-727, 1990.

89.Ewins DI, Wilkin TJ. A clinical comparison of the enzyme-linked immunosorbent assay (ELISA) and hemagglutination (TRC) in the routine detection of antithyroglobulin antibodies. Acta Endocrinol 103:216-222, 1983.

90.Takeda Y, Kriss JP. Radiometric measurement of thyroglobulin-antithyroglobulin immune complex in human serum. J Clin Endocrinol Metab 44:46, 1977.

91.Boyden SV. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med 93:107, 1951.

91.Vanderpump MPJ, Tunbridge WMG, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Hasan DM, Rodgers H, Tunbridge F, Young ET. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 43:55-68, 1995.

92.Williams ED, Doniach I. Post-mortem incidence of focal thyroiditis. J Pathol Bact 83:255, 1962.

93.Yoshida H, Amino N, Yagawa K, Uemura K, Satoh M, Miyai K, Kumahara Y. Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland. Studies of seventy autopsied cases. J Clin Endocrinol Metab 46:859, 1978.

94.Hjort T, Jeppesen F, Okholm K, Temler J. The prognostic significance of thyroid autoantibodies in the development of post-operative myxedema. Dan Med Bull 10:159, 1963.

95.Lundell G, Jonsson J. Thyroid antibodies and hypothyroidism in ¹³¹I therapy for hyperthyroidism. Acta Radiol 12:443, 1973.

96.Nordyke RA, Gilbert JR, FI, Miyamoto LA, Fleury KA. The superiority of antimicrosomal over antithyroglobulin antibodies for detecting Hashimoto’s thyroiditis. Arch Int Med 153:862-865, 1993.

97.Lindberg G, Svensson J, Ericsson U-B, Nilsson P, Svenonius E, Ivarsson S-A. Comparison of some different methods for analysis of thyroid autoantibodies: Importance of thyroglobulin autoantibodies. Thyroid 11:265-269, 2001.

98.Roman SH, Korn F, Davies TF. Enzyme-linked immunosorbent micro-assay and hemagglutination compared for detection of thyroglobulin and thyroid microsomal autoantibodies. Clin Chem 30:246-251, 1984.

99.Mariotti S, Anelli S, Ruf J, Bechi R, Czarnocka B, Lombardi A, Carayon P, Pinchera A: Comparison of serum thyroid microsomal and thyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab 65:987-993, 1987.

100. Okamoto Y, Hamada N, Saito H, Ohno M, Noh J, Ito K, Morii H: Thyroid peroxidase activity-inhibiting immunoglobulins in patients with autoimmune thyroid disease. J Clin Endocrinol Metab 68:730-734, 1989.

101.Trotter WR, Belvayin G, Waddams A. Precipitating and complement-fixing antibodies in Hashimoto's disease. Proc R Soc Med 50:961, 1957.

102.Pulvertaft RJV, Doniach D, Roitt IM, Hudson RV. Cytotoxic effects of Hashimoto serum on human thyroid cells in tissue culture. Lancet 2:214, 1959.

103.Chiovato L, Bassi P, Santini F, Mammoli C, Lapi P, Carayon P, Pinchera A. Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis. J Clin Endocrinol Metab 77:1700-1705, 1993.

104.Weetman AP, Cohen SB, Oleesky DA, Morgan BP. Terminal complement complexes and C1/C1 inhibitor complexes in autoimmune thyroid disease. Clin Exp Immunol 77:25-30, 1989.

105.Weetman AP, Freeman MA, Morgan BP. Thyroid follicular cell function after non-lethal complement membrane attack. Clin Exp Immunol 82:69-74, 1990.

106.Holborow EJ. Serum antinuclear factor and autoimmunity. Proc R Soc Med 53:625, 1960.

107.McDermott MT, West SG, Emlen JW, Kidd GS: Antideoxyribonucleic acid antibodies in Graves' disease. J Clin Endocrinol Metab 71:509-511, 1990.

108.Buchanan WW, Anderson JR, Goudie RB, Gray KG. A skin test in thyroid disease. Lancet 2:928, 1958.

109.Amino N, Hagen SR, Yamada N, Refetoff S. Measurement of circulating thyroid microsomal antibodies by the tanned red cell-hemagglutination technique. Its usefulness in the diagnosis of autoimmune thyroid disease. Clin Endocrinol 5:115, 1976.

110.Premachandra BN, Blumenthal HT. Abnormal binding of thyroid hormone in sera from patients with Hashimoto's disease. J Clin Endocrinol Metab 27:931, 1967.

111.Calder EA, Penhale WJ, McCleman D, Barnes EW, Irvine WJ. Lymphocyte dependent antibody-mediated cytotoxicity in Hashimoto's thyroiditis. Clin Exp Immunol 14:153, 1973.

112.Suzuki S, Mitsunaga M, Miyoshi M, Hirakawa S, Nakagawa O, Miura H, Ofuji T. Cytophilic antithyroglobulin antibody and antibody-dependent monocyte-mediated cytotoxicity in Hashimoto's thyroiditis. J Clin Endocrinol Metab 51:446, 1980.

113.Metcalfe RA, Oh YS, Stroud C, Arnold K, Weetman AP. Analysis of antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease. Autoimmunity 25:65-72, 1997.

114.Duthoit C, Estienne V, Delom F, Durand-Gorde J-M, Mallet B, Carayon P, Ruf J. Production of immunoreactive thyroglobulin C-terminal fragments during thyroid hormone synthesis. Endocrinology 141:2518-2525, 2000.

115.Nielson CH, Leslie RGQ, Jepsen BS, Kazatchkine MD, Kaveri SV, Fischer E. Natural autoantibodies and complement promote the uptake of a self antigen, human thyroglobulin, by B cells and the proliferation of thyroglobulin-reactive CD4 ⁺T cells in healthy individuals. Eur J Immunol 31:2660-2668, 2001.

116.Fenzi G, Hashizume K, Roudebush CP, DeGroot LJ. Changes in thyroid-stimulating immunoglobulins during antithyroid therapy. J Clin Endocrinol Metab 48:572, 1979.

117. Kaplan MM. Hypothyroidism after treatment with interleukin- 2 and lymphokine-activated killer cells. N Engl J Med 318:1557, 1988.

118.Carella C, Mazziotti G, Amato G, Braverman LE, Roti E. Interferon-α-related thyroid disease: pathophysiological, epidemiological and clinical aspects. J Clin Endocrinol Metab 89:3656-3661, 2004.

119.Henry M, Zanelli E, Piechaczyk M, et al. A major human thyroglobulin epitope defined with monoclonal antibodies is mainly recognized by human autoantibodies. Eur J Immunol 22:315-319, 1992.

120.Prentice L, Kiso Y, Fukuma N, Horimoto M, Petersen V, Grennan F, Pegg C, Furmaniak J, Rees Smith B. Monoclonal thyroglobulin autoantibodies: Variable region analysis and epitope recognition. J Clin Endocrinol Metab 80:977-986, 1995.

121.Tomer Y. Anti-thyroglobulin autoantibodies in autoimmune thyroid diseases: Cross-reactive or pathogenic? Clinl Immunol Immunopathol 82:3-11, 1997.

122.Libert F, Ludgate M, Dinsart C, Vassart G. Thyroperoxidase, but not the thyrotropin receptor, contains sequential epitopes recognized by autoantibodies in recombinant peptides expressed in the pUEX vector. J Clin Endocrinol Metab 73:857-860, 1991.

123.Nishikawa T, Rapoport B, McLachlan SM. The quest for the autoantibody immunodominant region on thyroid peroxidase: Guided mutagenesis based on a hypothetical three-dimensional model. Endocrinology 137:1000-1006, 1996.

124.Benveniste P, Wenzel BE, Khalil A, Row VV, Volpe R. Spontaneous secretion of thyroid autoantibodies by cultured peripheral blood lymphocytes from patients with Hashimoto's thyroiditis detected by micro-ELISA techniques. Clin Exp Immunol 58:273-282, 1984.

125.McLachlan SM, Pegg CAS, Atherton MC, Middleton SL, Dickinson A, Clark F, Proctor SJ, Proud G, Smith BR. Subpopulations of thyroid autoantibody secreting lymphocytes in Graves' and Hashimoto thyroid glands. Clin Exp Immunol 65:319-328, 1986.

126.McLachlan SM, Dickinson AM, Malcolm A, Farndon JR, Young E, Proctor SJ, Smith BR. Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte markers and response to pokeweed mitogen. Clin Exp Immunol 52:45-53, 1983.

127.Logtenberg T, Kroon A, Gmelig-Meyling FHJ, Ballieux RE. Production of anti-thyroglobulin antibody by blood lymphocytes from patients with autoimmune thyroiditis, induced by the insolubilized autoantigen. J Immunol 136:1236-1240. 1986.

128.McLachlan SM, Fawcett J, Atherton MC, Thompson P, Baylis P, Rees Smith B. Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. II. Effect of thyroglobulin on thyroglobulin antibody synthesis. Clin Exp Immunol 52:620-628, 1983.

129.Weetman AP, McGregor AM, Lazarus JH, Hall R. Thyroid antibodies are produced by thyroid-derived lymphocytes. Clin. Exp. Immunol. 48:196-200, 1982.

130.Armengol MP, Juan M, Lucas-Martin A, Fernández-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R. Demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing intrathyroidal germinal centers. Am J Pathol 159, 861-873, 2001.

131.Weetman AP, McGregor AM, Wheeler MH, Hall R. Extrathyroidal sites of autoantibody synthesis in Graves’ disease. Clin Exp Immunol 56:330-336, 1984.

132.Okita N, Kidd A, Row VV, Volpe R. Sensitization of T-lymphocytes in Graves' and Hashimoto's diseases. J Clin Endocrinol Metab 51:316, 1980.

133.Aoki N, DeGroot LJ. Lymphocyte blastogenic response to human thyroglobulin in Graves' disease, Hashimoto's thyroiditis, and metastatic thyroid cancer. Clin Exp Immunol 38:523-530, 1979.

134.Weetman AP. Autologous CD8-positive cells suppress T cell proliferation in response to thyroid antigens in Hashimoto’s thyroiditis. Clin Immunol Immunopathol 51:303-310, 1989.

135.Butscher WG, Ladenson PW, Burek CL. Whole-blood proliferation assay for autoimmune thyroid disease: Comparison to density-gradient sepaated-peripheral blood lymphocytes. Thyroid 11, 531-537, 2001.

136.Amino N, DeGroot LJ. Insoluble particulate antigen(s) in cell-mediated immunity of autoimmune thyroid disease. Metabolism 24:45-56, 1975.

137.Canonica GW, Cosulich ME, Croci R, Ferrini S, Bagnasco M, Dirienzo W, Ferrini O, Bargellesi A, Giordano G. Thyroglobulin-induced T-cell in vitro proliferation in Hashimoto's thyroiditis: identification of the responsive subset and effect of monoclonal antibodies directed to Ia antigens. Clin Immunol Immunopathol 32:132-141, 1984.

138.Canonica GW, Caria M, Bagnasco M, Cosulich ME, Giordano G, Moretta L. Proliferation of T8-positive cytolytic T lymphocytes in response to thyroglobulin in human autoimmune thyroiditis: analysis of cell interactions and culture requirements. Clin Immunol Immunopathol 36:40-48, 1985.

139.Lamki L, Row VV, Volpe R. Cell-mediated immunity in Graves' disease and in Hashimoto's thyroiditis as shown by the demonstration of migration inhibition factor (MIF). J Clin Endocrinol Metab 36:358, 1973.

140.Davies TF. Cocultures of human thyroid monolayer cells and autologous T cells: impact of HLA Class II antigen expression. J Clin Endocrinol Metab 61:418-422, 1985.

141.Weetman AP, Volkman DJ, Burman KD, Margolick JB, Petrick P, Weintraub BD, Fauci AS. The production and characterization of thyroid-derived T-cell lines in Graves' disease and Hashimoto's thyroiditis. Clin Immunol Immunopathol 39:139-150, 1986.

142.Londei M, Bottazzo GF, Feldmann M. Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228:85-88, 1985.

143.Soliman M, Kaplan E, Yanagawa T, Hidaka Y, Fisfalen M-E, DeGroot LJ. T-cells recognize multiple epitopes in the human thyrotropin receptor extracellular domain. J Clin Endocrinol Metab 80:905-914, 1995.

144.Martin A, Nakashima M, Zhou A, Aronson D, Werner AJ, Davies TF. Detection of major T cell epitopes on human thyroid stimulating hormone receptor by overriding immune heterogeneity in patients with Graves’ disease. J Clin Endocrinol Metab 82:3361-3366, 1997.

145.Sawai Y, DeGroot LJ. Binding of human thyrotropin receptor peptides to a Graves’ disease predisposing human leukocyte antigen class II molecule. J Clin Endocrinol Metab 85:1176-1179, 2000.

146.Davies TF, Martin A, Concepcion ES, Graves P, Lahat N, Cohen WL, Ben-Nun A. Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. J Clin Invest 89:157-162, 1992.

147.Davies TF, Concepcion ES, Ben-Nun A, Graves P, Tarjan G. T-cell receptor V gene use in autoimmune thyroid disease: Direct assessment by thyroid aspiration. J Clin Endocrinol Metab 76:660-666, 1993.

148.McIntosh RS, Tandon N, Pickerill AP, Davies R, Barnett D, Weetman AP. IL-2 receptor positive intrathyroidal lymphocytes in Graves’ disease: Analysis of Vα transcript microheterogeneity. J Immunol 91:3884-3893, 1993.

149.Caso-Peláez E, McGregor AM, Banga JP. A polyclonal T cell repertoire of V-alpha and V-beta T cell receptor gene families in intrathyroidal T lymphocytes of Graves’ disease patients. Scand J Immunol 41:141-147, 1995.

150.McIntosh RS, Watson PA, Weetman AP. analysis of T cell receptor Vα repertoire in Hashimoto’s thyroiditis: Evidence for the restricted accumulation of CD8 ⁺T cells in the absence of CD4 ⁺T cell restriction. J Clin Endocrinol Metab 82:1140-1146, 1997.

151.McMurray RW, Hoffman RW, Tang H, Braley-Mullen H. T cell repertoire Vβ usage in murine experimental autoimmune thyroiditis. Cell Immunol 172:1-9, 1996.

152.MacKenzie WA, Davies TF. An intrathyroidal T-cell clone speci-fically cytotoxic for human thyroid cells. Immunology 61:101-103, 1987.

153.Arao T, Morimoto I, Kakinuma A, Ishida O, Zeki K, Tanaka Y, Ishikawa N, Ito K, Ito K, Eto S. Thyrocyte proliferation by cellular adhesion to infiltrating lymphocytes through the intercellular adhesion molecule-1/lymphocyte function-associated antigen-1 pathway in Graves’ disease. J Clin Endocrinol Metab 85:382-389, 2000.

154.Ploth DW, Fitz A, Schnetzler D, Seidenfeld J, Wilson CB. Thyroglobulin-anti-thyroglobulin immune complex glomerulonephritis compli-cating radioiodine therapy. Clin Immunol Immunopathol 9:327-334, 1978.

155.O'Regan S, Fong JSC, Kaplan BS, de Chadarevian J-P, Lapointe N, Drummond KN. Thyroid antigen-antibody nephritis. Clin Immunol Immunopathol 6:341-346, 1976.

156.Weetman AP, Tandon N, Morgan BP. Antithyroid drugs and release of inflammatory mediators by complement-attacked thyroid cells. Lancet 340:633-636, 1992.

157.Endo Y, Aratake Y, Yamamoto I, Nakagawa H, Kuribayashi T, Ohtaki S. Peripheral K cells in Graves' disease and Hashimoto's thyroiditis in relation to circulating immune complexes. Clin Endocrinol 18:187-194, 1983.

158.Sack J, Baker JR Jr, Weetman AP, Wartofsky L, Burman KD. Killer cell activity and antibody-dependent cell-mediated cytotoxicity are normal in Hashimoto's disease. J Clin Endocrinol Metab 62:1059-1064, 1986.

159.Amino N, Mori H, Iwatani Y, Asari S, Izumiguchi Y, Miyai K. Peripheral K lymphocytes in autoimmune thyroid disease: decrease in Graves' disease and increase in Hashimoto's disease. J Clin Endocrinol Metab 54:587-591, 1982.

160.Bogner U, Schleusener H, Wall JR. Antibody-dependent cell mediated cytotoxicity against human thyroid cells in Hashimoto's thyroiditis but not Graves' disease. J Clin Endocrinol Metab 59:734-738, 1984.

161.Hidaka Y, Amino N, Iwatani Y, et al. Increase in peripheral natural killer cell activity in patients with autoimmune thyroid disease. Autoimmunity 11:239-246, 1992.

162.Bogner U, Hegedüs L, Hansen JM, Finke R, Schleusener H. Thyroid cytotoxic antibodies in atrophic and goitrous autoimmune thyroiditis. Europ J Endocrinol 132:69-74, 1995.

163.Bornet H, Orgiazzi J. Assessment of antibody dependent cell cytotoxicity in autoimmune thyroid disease using porcine thyroid cells. Autoimmunity 13:177-185, 1992.

164.Kung AWC, Lau LMA, Lau KS. The role of interferon-γ in lymphocytic thyroiditis: Its functional and pathological effect on human thyrocytes in culture. Clin Exp Immunol 87:261-265, 1992.

165.Weetman AP, Ajjan RA. Cytokines and autoimmune thyroid disease. (www.hotthyroidology.com) June, No 1, 2002.

166.Saavedra AP, Cass LA, Prendergast GV, Meinkoth JL. Differential effects of acute and chronic exposure to interferon-γ on cyclic adenosine 3’5’-monophosphate response element-regulated gene expression. Endocrinology 141:606-614, 2000.

167.Alimi E, Huang S, Brazillet M-P, Charreire J. Experimental autoimmune thyroiditis (EAT) in mice lacking the IFN-γ receptor gene. Eur J Immunol 28:201-208, 1998.

168.Simons PJ, Delemarre FGA, Drexhage HA. Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1β and interleukin-6. Endocrinology 139:3148-3156, 1998.

169.Nilsson M, Husmark J, Björkman U, Ericson LE. Cytokines and thyroid epithelial integrity: interleukin-1α induces dissociation of the junctional complex and paracellular leakage in filter-cultured human thyrocytes. J Clin Endocrinol Metab 83:945-952, 1998.

170.Itaka M, Miura S, Yamanaka K, Kawasaki S, Kitahama S, Kawakami Y, Kakinuma S, Oosuga I, Wada S, Katayama S. Increased serum vascular endothelial growth factor levels and intrathyroidal vascular area in patients with Graves’ disease and Hashimoto’s thyroiditis. J Clin Endocrinol Metab 83:3908-3912, 1998.

171.Weetman AP. Determinants of autoimmune thyroid disease. Nature Immunol 2:405, 2001.

172.Kite JH, Witebsky E. Hereditary autoimmune thyroiditis in the fowl. Science 160:1357, 1968.

173.Beierwaltes WH, Nishyama RH. Dog thyroiditis. Occurrence and similarity to Hashimoto's struma. Endocrinology 83:501, 1968.

174.Evans TC, Beierwaltes WH, Nishiyama RH. Experimental canine Hashimoto's thyroiditis. Endocrinology 84:641, 1969.

175.Kite JH, Argue H, Rose NR. Experimental thyroiditis in the rhesus monkey. I. Cytotoxic, mixed-agglutinating and complement-fixing antibodies. Clin Exp Immunol 1:139, 1966.

176.Beall GN, Daniel PM, Pratt OE, Solomon DH. Effects of immunization of baboons with human thyroid tissue. J Clin Endocrinol Metab 29:1460, 1969.

177.Weigle WO, Nakamura RM. The development of autoimmune thyroiditis in rabbits following injection of aqueous preparations of heterologous thyroglobulins. J Immunol 99:223, 1967.

178.Dawe KI, Hutchings PR, Geysen M, Champion BR, Cooke A, Roitt IM. Unique role of thyroxine in T cell recognition of a pathogenic peptide in experimental autoimmune thyroiditis. Europ J Immunol 26:768-772, 1996.

179.Kong Y-C, McCormick DJ, Wan Q, Motte RW, Fuller BE, Giraldo AA, David CS. Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. J Immunol 155:5847-5854, 1995.

180.Carayanniotis G, Rao VP. Searching for pathogenic epitopes in thyroglobulin: parameters and caveats. Immunol Today 18:83-88, 1997.

181.Sugihara S, Fujiwara H, Shearer GM. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. J Immunol 150:683-694, 1993.

182.Tomer Y, Gilburd B, Sack J, Davies TF, Meshorer A, Burek CL, Rose NR, Shoenfeld Y. Induction of thyriod autoantibodies in naive mice by idiotypic manipulation. Clin Immunol Immunopathol 78:180-187, 1996.

183.Flynn JC, Conaway DH, Cobbold S, Waldmann H, Kong Y-CM. Depletion of L3T ₄+ and Lyt-2+ cells by rat monoclonal antibodies alters the development of adoptively transferred experimental autoimmune thyroiditis. Cell Immunol 122:377-390, 1989.

184.Maron R, Zerubavel R, Friedman A, Cohen IR. T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J Immunol 131:2316-2322, 1983.

185.Taguchi O, Takahashi T. Mouse models of autoimmune disease suggest that self-tolerance is maintained by unresponsive autoreactive T cells. Immunology 89:13-19, 1996.

186.Guimaraes VC, Quintans J, Fisfalen M-E, Straus FH, Wilhelm K, Medeiros-Neto GA, DeGroot LJ. Suppression of development of experimental autoimmune thyroiditis by oral administration of thyroglobulin. Endocrinology 136:3353-3359, 1995.

187. Gangi E, Vau C, Cheatam D, Prabhakar B. IL-10-producing CD4 ⁺, CD25 ⁺regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J Immunol 174: 7006-7013, 2005.

188. Verginis P, Li HS, Carayanniotis G. Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4 ⁺, CD25 ⁺T cells. J Immunol 174, 7433-7439, 2005.

190. Ng HP, Banga JP, Kung AWC. Development of a murine model of autoimmune thyroiditis induced with homologous mouse thyroid peroxidase. Endocrinolgy 145: 809-816, 2004.

191.Pichurin P, Chen C-R, Pichurina O, David C, Rapoport B, McLachlan SM. Throtropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. Thyroid 13:911-917, 2003.

192.Nagayama Y, McLachlan SM, Rapoport B, Niwa M. A major role for non-major histocompatibility complex genes but not for microorganisms in a novel murine model of Graves’ hyperthyroidism. Thyroid 13:233-238, 2003.

193.Bagchi N, Brown TR, Sundick RS. Thyroid cell inuury is an initial event in the induction of autoimmune thyroiditis by iodine in obese strain chickens. Endocrinology 136:5054-5060, 1995.

193a. Flynn JC, Meroueh C, Snower DP, David CS, Kong YM.Depletion of CD4 ⁺CD25 ⁺regulatory T cells exacerbates sodium iodide-induced experimental autoimmune thyroiditis in human leucocyte antigen DR3 (DRB1*0301) transgenic class II-knock-out non-obese diabetic mice. Clin Exp Immunol.147:547-54, 2007.

194.Bagchi N, Sundick RS, Hu LH, Cummings GD, Brown TR. Distinct regions of thyroglobulin control the proliferation and suppression of thyroid-specific lymphocytes in obese strain chickens. Endocrinology 137:-3286-3390, 1996.

195.Damotte D, Colomb E, Cailleau C, Brousse N, Charreire J, Carnaud . Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. Europ J Immunol 27:2854-2862, 1997.

196.Allen EM, Appel MC, Braverman LE. Iodine-induced thyroiditis and hypothyroidism in the hemithyroidectomized BB/W rat. Endocrinology 121:481-485, 1987.

197.Penhale WJ, Farmer A, McKenna RP, Irvine WJ. Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. Clin Exp Immunol 15:225-236, 1973.

198.Sempowski GD, Cross SJ, Heinly CS, Scearce RM, Haynes BF. CD7 and CD28 are required for murine CD4 ⁺,CD25 ⁺regulatory T cell homeostasis and prevention of thyroiditis. J Immunol 172, 787-794, 2004.

199. Quarantino S, Badami E, Pang YY, Bartok I, Dyson J, Kioussis D, Londei M, Maiuri L. Degenerate self-reactive human T cell receptor causes spontaneous autoimmune disease in mice. Nature Med 10:920-926, 2004.

200. Li HS, Verginis P, Carayanniotis G.Maturation of dendritic cells by necrotic thyrocytes facilitates induction of experimental autoimmune thyroiditis.Clin Exp Immunol. 144:467-74, 2006

201. Kohn LD, Shimojo N, Kohno Y, Suzuki K. An animal model of Graves’ disease: Understanding the cause of autoimmune hyperthyroidism. Rev Endocr Met Dis 1:59-67, 2000

202. McLachlan SM, Nagayama Y, Rapoport B. Insight into Graves’ hyperthyroidism from animal models. Endocrine Rev 26: 800-832, 2005.

203.Jaume JC, Guo J, Wang Y, Rapoport B, McLachlan SM. Cellular thyroid peroxidase (TPO), unlike purified TPO and adjuvant, induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease. J Clin Endocrinol Metab 84: 1651-1657, 1999.

204. Pichurin PN, Pichurina O, Marians RC, Chen CR, Davies TF, Rapop0rt B, McLachlan SM. Thyrotropin receptor knockout mice: studies on immunological tolerance to a major thyroid autoantigen. Endocrinology 145:1294-1301,2004.

205. Baker G, Mazziotti G, von Ruhland C, Ludgate M. Re-evaluating thyrotropin receptor-induced mouse models of Graves’ disease. Endocrinol 146:835-844, 2005.

206.Ando T, Imaizumi M, Graves P, Unger P, Davies TF. Induction of thyroid-stimulating hormone receptor autoimmunity in hamsters. Endocrinol 144:671-680, 2003.

207.Sugihara S, Fujiwara H, Niimi H, Shearer GM. Self-thyroid epithelial cell (TEC)-reactive CD8 ⁺T cell lines/clones derived from autoimmune thyroiditis lesions. J Immunol 155:1619-1628, 1995.

208.Catálfamo M, Roura-Mir C, Sospedra M, Aparicio P, Costagliola S, Ludgate M, Pujol-Borrell R, Jaraquemada D. Self-reactive cytotoxic γδ T lymphocytes in Graves’ disease specifically recognize thyroid epithelial cells. J Immunol 156:804-811, 1996.

209.Wu Z, Podack ER, McKenzie JM, Olsen KJ, Zakarija M. Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease. Clin Exp Immunol 98:470-477, 1994.

210.Giordano C, Stassi G, De Maria R, Todaro M, Richiusa P, Papoff G, Ruberti G, Bagnasco M, Testi R, Galluzzo A. Potential involvement of Fas and its ligand on the pathogenesis of Hashimoto’s thyroiditis. Science 275:960-963, 1997.

211.Kawakami A, Eguchi K, Matsuoka N, Tsuboi M, Yrayama S, Kawabe Y, Tahara K, Ishikawa N, Ito K, Nagataki S. Modulation of Fas-mediated apoptosis of human thyroid epithelial cells by IgG from patients with Graves’ disease (GD) and idiopathic myxoedema. Clin Exp Immunol 110:434-439, 1997.

212.Stassi G, Todaro M, Bucchieri F, Stoppacciaro A, Farina F, Zummo G, Testi R, De Maria R. Fas/Fas ligand-driven T cell apoptosis as a consequence of ineffective thyroid immunoprivilege in Hashimoto’s thyroiditis. J Immunol 162: 263-267, 1999.

213.Giordano C, Richiusa P, Bagnasco M, Pizzolanti G, Di Blasi F, Sbriglia MS, Mattina A, Pesce G, Montagna P, Capone F, Misiano G, Scorsone A, Publiese A, Galluzzo A. Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease. Thyroid 11:233-244, 2001.

214.Baker Jr JR. Guest editorial. Thyroid 11:245-247, 2001.

215.Kasai K, Hattori Y, Nakanishi N, Manaka K, Banba N, Motohashi S, Shimoda S-I. Regulation of inducible nitric oxide production by cytokines in human thyrocytes in culture. Endocrinology 136:4261-4270, 1995.

216.Lidman K, Eriksson U, Norberg R, Fagraeus A. Indirect immunofluorescence staining of human thyroid by antibodies occurring in Yersinia enterocolitica infections. Clin Exp Immunol 23:429-435, 1976.

217.Costagliola S, Ruf J, Durand-Gorde M-J, Carayon P. Monoclonal anti-idiotypic antibodies interact with the 93 kilodalton thyrotropin receptor and exhibit heterogeneous biological activities. Endocrinology 128:1555-1562, 1991.

218. Dziarski R. Autoimmunity: polyclonal activation or antigen induction? Immunol Today, 9:340-342, 1988.

219.Tomer Y, Davies TF. Infection, thyroid disease, and autoimmunity. Endocrine Rev 14:107-120, 1993.

220.Bartalena L, Bogazzi F, Pecori F, Martino E. Graves’ disease occurring after subacute thyroiditis: Report of a case and review of the literature. Thyroid 6:345-348, 1996.

221.Vykhovanets EV, Chernyshov VP, Slukvin II, Antipkin YG, Vasyuk AN, Klimenko HF, Strauss KW. ¹³¹I dose-dependent thyroid autoimmune disorders in children living around Chernobyl. Clin Immunol Immunopathol 84:251-259, 1997.

222.Vermiglio F, Castagna MG, Volnova E, Lo Presti VP, Moleti M, Violi MA, Artemisia A, Trimarchi F. Post-Chernobyl increased prevalence of humoral thyroid autoimmunity in children and adolescents from a moderately iodine-deficient area in Russia. Thyroid 9: 781-786, 1999.

223. Volzke H, Werner A, Wallaschofski H et al. Occupational exposure to ionizing radiation is associated with autoimmune thyroid disease. J Clin Endocrinol Metab 90: 4587-4592, 2005.

224.Van Herle AJ, Uller RP, Mathews NL, Brown J. Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest 52:1320,1973.

225.Tandon N, Freeman MA, Weetman AP. T cell responses to synthetic THS receptor peptides in Graves’ disease. Clin Exp Immunol 89:468-473, 1992.

226.Chiovato L, Latrofa F, Braverman LE, Pacini F, Capezzone M, Masserini L, Grasso L, Pinchera A. Disappearance of humoral thyroid autoimmunity after complete removal of thyroid antigens. Ann Intern Med 139:346-351, 2003.

227.Klintschar M, Schwaiger P, Mannweiler S, Regauer S, Kleiber M. Evidence of fetal microchimerism in Hashimoto’s thyroiditis. J Clin Endocrinol Metab 86:2494-2498, 2001.

228.Imaizumi M, Pritsker A, Unger P, Davies TF. Intrathyroidal fetal microchimerism in pregnancy and postpartum. Endocrinology 143:247-253, 2002.

229. Bulow Pedersen I, Laurberg P, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Rasmussen LB.Lack of association between thyroid autoantibodies and parity in a population study argues against microchimerism as a trigger of thyroid autoimmunity. Eur J Endocrinol. 154:39-45, 2006.

230. Brix TH, Knudsen GPS, Kristiansen M, Kyvik KO, Orstavik KH, Hegedus L. High frequency of skewed X-inactivation in females with autoimmune thyroid disease: a possible explanation for female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab 90: 5949-5953, 2005.

231.Weiss M, Ingbar SH, Winblad S, Kasper DL. Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica. Science 219:1331-1333, 1983.

232.Wolf MW, Misaki T, Bech K, Tvede M, Silva JE, Ingbar SH: Immunoglobulins of patients recovering from Yersinia enterocolitica infections exhibit Graves' disease-like activity in human thyroid membranes. Thyroid 1:315, 1991.

233.Wenzel BE, Heesemann J, Wenzel KW, Scriba PC. Patients with autoimmune thyroid diseases have antibodies to plasmid encoded proteins of enteropathogenic Yersinia. J Endocrinol Invest 11:139-140, 1988.

234.Arscott P, Rosen ED, Koenig RJ, Kaplan MM, Ellis T, Thompson N, Baker JR. Immunoreactivity to Yersinia enterocolitica antigens in patients with autoimmune thyroid disease. J Clin Endocrinol Metab 75:295-320, 1992.

235.Ratanachaiyavong S, Demaine AG, Campbell RD, McGregor AM. Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease. Clin Exp Immunol 84:48-52, 1991.

236.Heufelder AE, Wenzel BE, Gorman CA, Bahn RS. Detection, cellular localization, and modulation of heat shock proteins in cultured fibroblasts from patients with extrathyroidal manifestations of Graves' disease. J Clin Endocrinol Metab 73:739-745, 1991.

237.Ruf J, Feldt-Rasmussen U, Hegedus L, Ferrand M, Carayon P. Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. J Clin Endocrinol Metab 79:1404-1409, 1994.

238.Quaratino S, Thorpe CJ, Travers PJ, Londei M. Similar antigenic surfaces, rather than sequence homology, dictate T-cell epitope molecular mimicry. Proc Natl Acad Sci USA 92:10398-10402, 1995.

239.Epstein FH. Molecular mimicry and autoimmunity. New Engl J Med 341:2068-2074, 1999.

240. Klavinskis LS, Notkins AL, Oldstone MBA. Persistent viral infection of the thyroid gland: alteration of thyroid function in the absence of tissue injury. Endocrinology 122:567-575, 1988.

241.Jaspan JB, Sullivan K, Garry RF, Lopez M, Wolfe M, Clejan S, Yan C, Tenenbaum S, Sander DM, Ahmed B, Bryer-ash M. The interaction of a type A retroviral particle and class II human leukocyte antigen susceptibility genes in the pathogenesis of Graves’ disease. J Clin Endocrinol Metab 81:2271-2279, 1996.

242.Nagasaka A, Nakai A, Oda N, Kotake M, Iwase K, Yoshida S. Reverse transcriptase is elevated in the thyroid tissue from Graves’ disease patients. Clin Endocrinol 53:155-159, 2000.

243.Tomoyose T, Komiya I, Takara M, Yabiku K, Kinjo Y, Shimajiri Y, Yogi H, Kouki T, Masuda M, Takasu N. Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto’s thyroiditis in Japanese patients. Thyroid 12:673-677, 2002.

244.Knight J, Laing P, Knight A, Adams D, Ling N. Thyroid-stimulating autoantibodies usually contain only lambda-light chains: evidence for the "forbidden clone" theory. J Clin Endocrinol Metab 62:342-347, 1986.

245.Brix TH, Christensen K, Holm NV, Harvald B, Hegedüs L. A population-based study of Graves’ disease in Danish twins. Clin Endocrinol 48:397-400, 1998.

246.Bartels ED. Heredity in Graves' disease. Copenhagen, Enjnar Munksgaards Forlag, 1941.

247.Brix TH, Kyvik KO, Hegedüs L. What is the evidence of genetic factors in the etiology of Graves’ disease? A brief review. Thyorid 8:727-734, 1998.

248.Brix T, Kyvik KO, Hegedüs L. A population-based study of chronic autoimmune hypothyroidism in Danish twins. J Clin Endocrinol Metab 85:536-539, 2000.

249.Brix TH, Kyvik KO, Christensen K, Hegedüs L. Evidence for a major role of heterdity in Graves’ disease: A population-based study of two Danish twin cohorts. J Clin Endocrinol Metab 86:930-934, 2001.

250.Ringold DA, Nicoloff JT, Kesler M, Davis H, Hamilton A, Mack T. Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: The California twin study. Thyroid 12:647-653, 2002.

251. Hall R, Owen SG, Smart GA. Evidence for genetic predisposition to formation of thyroid auto-antibodies. Lancet 2:187, 1960.

252.Phillips D, Prentice L, Upadhyaya M, Lunt P, Chamberlain S, Roberts DF, McLachlan S, Smith BR. Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease. J Clin Endocrinol Metab 72:973-975, 1991.

253.Phillips DIW, Shields DC, Dougoujon JM, Prentice L, McGuffin P, Rees Smith B. Complex segregation analysis of thyroid autoantibodies: Are they inherited as an autosomal dominant trait? Hum Hered 43:141-146, 1993.

254.Tomer Y, Davies TF. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocrine Reviews 24:694-717, 2003.

255.Weetman AP, McGregor AM. Autoimmune thyroid disease: Further developments in our understanding. Endocrine Rev 15:788-830, 1994.

256.Parkes AB, Darke C, Othman S, Thomas M, Young N, Richards CJ, Hall R, Lazarus JH. Major histocompatibility complex class II and complement polymorphisms in postpartum thyroiditis. Europ J Endocrinol 134:449-453, 1996.

257.Yanagawa T, Mangklabruks A, Chang Y-B, Okamoto Y, Fisfalen M-E, Curran PG, DeGroot LJ. Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population. J Clin Endocrinol Metab 76:1569-1574, 1993.

258.Chen Q-Y, Huang W, She J-X, Baxter F, Volpe R, Maclaren NK. HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves’ disease in North American Caucasians, whereas DRB1*07 is protective. J Clin Endocrinol Metab 84: 3182-3186, 1999.

259.Stenszky V, Kozma L, Balázs C, Rochlitz S, Bear JC, Farid NR. The genetics of Graves’ disease: HLA and disease susceptibility. J Clin Endocrinol Metab 61:735-740, 1985.

260.Shields DC, Ratanachaiyavong S, McGregor AM, Collins A, Morton NE. Combined segregation and linkage analysis of Graves’ disease with a thyroid autoantibody diathesis. Amer J Hum Genet 55:540-554, 1994.

261.Tomer Y, Barbesino G, Kedache M, Greenberg DA, Davies TF. Mapping of a major susceptibility locus for Graves’ disease (GD-1) to chromosome 14q31. J Clin Endocrinol Metab 82:1645-1648, 1997.

262.Yanagawa T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ. CTLA-4 gene polymorphism associated with Graves’ disease in Caucasian population. J Clin Endocrinol Metab 80:41-45, 1995.

263.Kotsa K, Watson PF, Weetman AP. A CTLA-4 gene polymorphism is associated with both Graves’ disease and autoimmune hypothyroidism. Clin Endocrinol 46:551-554, 1997.

264.Villanueva R, Inzerillo AM, Tomer Y, Barbesino G, Meltzer M, Concepcion ES, Greenberg DA, MacLaren N, Sun ZS, Zhang DM, Tucci S, Davies TF. Limited genetic susceptibility to severe Graves’ ophthalmopathy: No role for CTLA-4 but evidence for an environmental etiology. Thyroid 10:791-798, 2000.

265.Kinjo Y, Takasu N, Komiya I, Tomoyose T, Takara M, Kouki T, Shimajiri Y, Yabiku K, Yoshimura H. Remission of Graves’ hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecular-4 gene. J Clin Endocrinol Metab 87:2593-2596, 2002.

265a. Wang PW, Chen IY, Liu RT, Hsieh CJ, Hsi E, Juo SH.Cytotoxic T lymphocyte-associated molecule-4 gene polymorphism and hyperthyroid Graves' disease relapse after antithyroid drug withdrawal: a follow-up study. J Clin Endocrinol Metab. 92:2513-8, 2007.

266.Ueda H, Howson JMM, Esposito L, Heward J, Snool Hywel, Chamberlain G, Rainbow DB, Huner KMD, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RCJ, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia Am Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehot J, Bingley P, Gillespie KM, Undlein DE, RØnningen KS, Guja C, Ionescu-Tirgovişte C, Savage DA, Maxwell AP. Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SCL. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506-511, 2003..

267.Ban Y, Ban Y, Taniyama M, Katagiri T. Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves’ disease. Thyroid 16:475-480, 2000.

268.Collins JE, Heward JM, Nithiyananthan R, Nejentsev S, Todd JA, Franklyn JA, Gough SCL. Lack of an association of the vitamin D receptor gene with Graves’ disease in UK Caucasians, Clin Endocrinol 60:618-624,2004.

269. Simmonds MJ, Heward JM, Carr-Smith J, Foxall H, Franklyn JA, Gough SC.Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. J Clin Endocrinol Metab. 91:1056-61, 2006.

269a. Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 39:1329-37, 2007.

270.Velaga MR, Wilson V, Jennings CE, Owen CJ, Herington S, Donaldson PT, Ball SG, James RA, Quinton R, Perros P, Pearce SHS. The codon 620 tryptophan allele of the lymphoid tyrosine phosphates (LYP) gene is a major determinant of Graves’ disease. J Clin Endocrinol Metab 89: 5862-5865, 2004.

271. Dechairo BM, Zabaneh D, Collins J, Brand O, Dawson GJ, Green AP, Mackay I, Franklyn JA, Connell JM, Wass JA, Wiersinga WM, Hegedus L, Brix T, Robinson BG, Hunt PJ, Weetman AP, Carey AH, Gough SC.Association of the TSHR gene with Graves' disease: the first disease specific locus. Eur J Hum Genet. 131: 223-30, 2005.

271a. Heward JM, Brand OJ, Barrett JC, Carr-Smith JD, Franklyn JA, Gough SC.Association of PTPN22 haplotypes with Graves' disease. J Clin Endocrinol Metab. 92:685-90, 2007.

271b. Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SC.Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf). 66:508-12, 2007.

.

272.Barbesino G, Tomer Y, Concepcion ES, Davies TF, Greenberg DA and the International Consortium for the Genetics of Autoimmune Thyroid Disease. Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. J Clin Endocrinol Metab 83: 3290-3295, 1998.

273. Taylor JC, Gough SC, Hunt PJ, Brix TH, Chatterjee K, Connell JM, Franklyn JA, Hegedus L, Robinson BG, Wiersinga WM, Wass JA, Zabaneh D, Mackay I, Weetman AP.A genome-wide screen in 1119 relative pairs with autoimmune thyroid disease. J Clin Endocrinol Metab. 2005 Nov 8 (epub ahead of print).

274.Elsheikh M, Wass JAH, Conway GS. Autoimmune thyroid disease in women with Turner’s syndrome - the association with karyotype. Clin Endocrinol 55:223-226, 2001.

275.Imrie H, Vaidya B, Perros P, Kelly WF, Toft AD, Young ET, Kendall-Taylor P, Pearce SHS. Evidence for a Graves’ disease susceptibility locus at chromosome Xq11 in a United Kingdom population. J Clin Endocrinol Metab 86:626-530, 2001.

276. Brix TH, Hansen PS, Rudbeck AB, Hansen JB, Skytthe A, Kyvik KO, Hegedus L.Low birth weight is not associated with thyroid autoimmunity: a population-based twin study. J Clin Endocrinol Metab. 91:3499-502, 2006.

276a. Kajantie E, Phillips DI, Osmond C, Barker DJ, Forsén T, Eriksson JG.Spontaneous hypothyroidism in adult women is predicted by small body size at birth and during childhood. J Clin Endocrinol Metab. 91:4953-6, 2006.

276b. Radetti G, Fanolla A, Pappalardo L, Gottardi E.Prematurity may be a risk factor for thyroid dysfunction in childhood. J Clin Endocrinol Metab. 92:155-9, 2007.

277.Jenkins RC, Weetman AP. Disease associations with autoimmune thyroid disease. Thyroid 12:975-986, 2002.

278.Irvine WJ, Davies SH, Teitelbaum S, Delamore IW, Williams AW. The clinical and pathological significance of gastric parietal cell antibody. Ann NY Acad Sci 124:657, 1965.

279.Doniach D, Roitt IM, Taylor KB. Autoimmune phenomena in pernicious anemia. Serological overlap with thyroiditis, thyrotoxicosis, and systemic lupus erythematosus. Br Med J 1:1374, 1963.

280.Tudhope GR, Wilson GM. Deficiency of vitamin B12 in hypothyroidism. Lancet 1:703, 1962.

281.Buchanan WW, Crooks J, Alexander WD, Koutras DA, Wayne EJ, Gray KG. Association of Hashimoto's thyroiditis and rheumatoid arthritis. Lancet 1:245, 1961.

282.Mulhern LM, Masi AT, Shulman LE. Hashimoto's disease. A search for associated disorders in 170 clinically detected cases. Lancet 2:508, 1966.

283.Morita H, Arima T, Matsuda M. Prevalence of nonthyroid specific autoantibodies in autoimmune thyroid diseases. Journal of Clinical Endocrinology and Metabolism 80:1203-1206, 1995.

284.Neufeld M, Maclaren NK, Blizzard RM. Two types of autoimmune Addison’s disease associated with different polyglandular autoimmune (PGA) syndromes. Medicine 60:355-362, 1981.

285.Weetman AP. Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity. Balliere’s Clin Endocrinol Metab 9:157-174, 1995.

286.Falorni A, Laureti S, Santeusanio F. Autoantibodies in autoimmune polyendocrine syndrome type II. Endocrinol Metab Clin N Am 31:369-389, 2002.

287.Ahonen P, Myllärniemi S, Sipilä I, Perheentupa J. Clinical variation of autoimmune polyendocrinopathy - candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 322:1829-1836, 1990.

288.Nithiyamanthan R, Heward JM, Allahabadia A, Barnett AJ, Franklyn JA, Gough SCL. A heterozygous deletion of the autoimmune receptor (AIRE1) gene, autoimmune thyroid disease, and type 1 diabetes: No evidence for association. J Clin Endocrinol Metab 85:1320-1322, 2000.

289.Sridama V, Pacini F, DeGroot LJ. Decreased suppressor T lymphocytes in autoimmune thyroid diseases detected by monoclonal antibodies. J Clin Endocrinol Metab 54:316-319, 1982.

290.Pacini F, DeGroot LJ. Studies of immunoglobulin synthesis in cultures of peripheral T and B lymphocytes: Reduced T-suppressor cell activity in Graves’ disease. Clin Endocrinol 18L219-232, 1983.

291.Fournier C, Chen H, Leger A, Charreire J. Immunological studies of autoimmune thyroid disorders: abnormalities in the inducer T cell subset and proliferative responses to autologous and allogeneic stimulation. Clin Exp Immunol 54:539-546, 1983.

292.Ludgate ME, McGregor AM, Weetman AP, Ratanachaiyavong S, Lazarus JH, Hall R, Middleton GW. Analysis of T cell subsets in Graves' disease: alterations associated with carbimazole. Br Med J 288:526-530, 1984.

293.Misaki T, Konishi J, Iida Y, Endo K, Torizuka K. Altered balance of immunoregulatory T lymphocyte subsets in autoimmune thyroid diseases. Acta Endocrinol 105:200-204, 1984.

294.Volpe R, Karlsson A, Jansson R, Dahlberg PA. Evidence that antithyroid drugs induce remissions in Graves' disease by modulating thyroid cellular activity. Clin Endocrinol 25:453-462, 1986.

295. How J, Topliss DJ, Strakosch C, Lewis M, Row VV, Volpe R.T lymphocyte sensitization and suppressor T lymphocyte defect in patients long after treatment for Graves' disease. Clin Endocrinol 18:61-71, 1983.

296.Okita N, How J, Topliss D, Lewis M, Row VV, Volpe R. Suppressor T lymphocyte dysfunction in Graves' disease: role of the H-2 histamine receptor-bearing suppressor T lymphocytes. J Clin Endocrinol Metab 53:1002-1007, 1981.

297.Goldrath N, Shoham J, Bank H, Eisenstein Z. Antithyroid drugs and lymphocyte function. II. The in vivo effect on blastogenesis and suppressor cell activity in Graves' disease. Clin Exp Immunol 50:62-69, 1982.

298. Hallengren B, Forsgren A. Suppressor T lymphocyte function in Graves' disease. Acta Endocrinol 101:354-358, 1982.

299. Sridama V, Pacini F, Yang S-L, Moawad A, Reilly M, DeGroot LJ. Decreased levels of helper T cells. A possible cause of immunodeficiency in pregnancy. N Engl J Med 307:352- 356, 1982.

300.Jansson R, Bernander S, Karlsson A, Levin K, Nilsson G. Autoimmune thyroid dysfunction in the postpartum period. J Clin Endocrinol Metab 58:681, 1984.

301.Jackson RA, Haynes BF, Burch WM, Shimizu K, Bowring MA, Eisenbarth GS. Ia+ T cells in new onset Graves' disease. J Clin Endocrinol Metab 59:187-190, 1984.

302. Koukkou E, Panayiotidis P, Alevizou-Terzaki V, Thalassinos N: High levels of serum soluble interleukin-2 receptors in hyperthyroid patients: Correlation with serum thyroid hormones and independence from the etiology of the hyperthyroidism. J Clin Endocrinol Metab 73:771-776, 1991.

303.Noma T, Yata J, Shishiba Y, Inatsuki B. In vitro detection of anti-thyroglobulin antibody forming cells from the lymphocytes of chronic thyroiditis patients and analysis of their regulation. Clin Exp Immunol 49:565-571, 1982.

304.Mori H, Hamada N, DeGroot, LJ. Studies on thyroglobulin-specific suppressor T cell function in autoimmune thyroid disease. J Clin Endocrinol Metab 61:306-312, 1985.

305.Iitaka M, Aguayo JF, Iwatani Y, Row VV, Volpe R. Studies of the effect of suppressor T lymphocytes on the induction of antithyroid microsomal antibody secreting cells in autoimmune thyroid disease. J Clin Endocrinol Metab 66:1988.

306.Tao T-W, Gatenby PA, Leu S-L, Pham H, Kriss JP. Helper and suppressor activities of lymphocyte subsets on antithyroglobulin production in vitro. J Clin Endocrinol Metab 61:520-524, 1985.

307. Vento S, Hegarty JE, Bottazzo G, Macchia E, Williams R, Eddleston AL. Antigen specific suppressor cell function in autoimmune chronic active hepatitis. Lancet 2:1200-1204, 1984.

308.Yoshikawa N, Morita T, Resetkova E, Arreanza G, Carayon P, Volpe R. Reduced activation of suppressor T lymphocytes by specific antigens in autoimmune thyroid disease. J Endocrinol Invest 15:609-617, 1992.

309.Ludgate ME, Ratanchaiyavong S, Weetman AP, Hall R, McGregor AM. Failure to demonstrate cell-mediated immune responses to thyroid antigens in Graves’ disease using in vitro assays of lymphokine-mediated migration inhibition. Journal of Clinical Endocrinology and Metabolism 60:98-102, 1985.

310.Bloom BR, Salgame P, Diamond B. Revisiting and revising suppressor T cells. Immunology Today 13:131-136, 1992.

311.Cone RE, Malley A. Soluble, antigen-specific T-cell proteins: T-cell-based humoral immunity? Immunol Today 17:318-322, 1996.

312. Marazuela M, Garcia-Lopez MA, Figueroa-Vega N, de la Fuente H, Alvarado-Sanchez B, Monsivais-Urenda A, Sanchez-Madrid F, Gonzalez-Amaro R.Regulatory T cells in human autoimmune thyroid disease.J Clin Endocrinol Metab. 2006;91:3639-46.

313.Margolick JB, Hsu S-M, Volkman DJ, Burman KD, Fauci AS. Immunohistochemical characterization of intrathyroid lymphocytes in Graves' disease. Interstitial and intraepithelial populations. Amer J Med 76:815-821, 1984.

314.Canonica GW, Caria M, Torre G, Risso A, Cosulich ME, Bagnasco M. Autoimmune thyroid disease: purification and phenotypic analysis of intrathyroid T cells. J Endocrinol Invest 7:641, 1984.

315.Misaki T, Konishi J, Arai K, Iida Y, Kasagi K, Kuma K, Torizuka K. HLA-DR antigen expression on intrathyroidal lymphocytes and thyrocytes in Hashimoto's thyroiditis and Graves' disease: an immunohistological study. Endocrinol Japon 34:257-262, 1987.

316.Ashhab Y, Dominguez O, Sospedra M, Roura-Mir C, Lucas-Martin A, Pujol-Borrell R. A one-tube polymerase chain reaction protocol demonstrates CC chemokine overexpression in Graves’ disease glands. J Clin Endocrinol Metab 84: 2873-2882, 1999.

317.Ueki Y, Eguchi K, Otsubo T, Kawabe Y, Shimomura C, Matsunaga M, Tezuka H, Nakao H, Kawakami A, Izumi M, Ishikawa N, Ito K, Nagataki S. Phenotypic analyses and Concanavalin-A- induced suppressor cell dysfunction of intrathyroidal lymphocytes from patients with Graves' disease. J Clin Endocrinol Metab 67:1018-1024, 1988.

318.Tezuka H, Eguchi K, Fukuda T, Otsubo T, Kawabe Y, Ueki Y, Matsunaga M, Shimomura C, Nakao H, Ishikawa N, Ito K, Nagataki S. Natural killer and natural killer-like cell activity of peripheral blood and intrathyroidal mononuclear cells from patients with Graves' disease. J Clin Endocrinol Metab 66:702, 1988.

319.Bagnasco M, Venuti D, Prigione I, Torre GC, Ferrini S, Canonica GW. Graves' disease: phenotypic and functional analysis at the clonal level of the T-cell repertoire in peripheral blood and in thyroid. Clin Immunol Immunopathol 47:230-239, 1988.

320.Del Prete GF, Maggi E, Mariotti S, Tiri A, Vercelli D, Parronchi P, Macchia E, Pinchera A, Ricci M, Romagnani S. Cytolytic T lymphocytes with natural killer activity in thyroid infiltrate of patients with Hashimoto's thyroiditis: analysis at clonal level. J Clin Endocrinol Metab 62:52, 1986.

321.Ajjan RA, Watson PF, McIntosh RS, Weetman AP. Intrathyroidal cytokine gene expression in Hashimoto’s thyroiditis. Clin Exp Immunol 105:523-528, 1996.

322.Yang D, Hiromatsu Y, Hoshino T, Inoue Y, Itoh K, Nonaka K. Dominant infiltration of TH1-type CD4 ⁺T cells at the retrobulbar space of patients with thyroid-associated ophthalmopathy. Thyroid 9: 305-310, 1999.

323.Pichurin P, Pichurina O, Chazenbalk GD, Paras C, Chen C-R, Rapoport B, McLachlan SM. Immune deviation away from Th1 in interferon-γ knockout mice does not enhance TSH receptor antibody production after naked DNA vaccination. Endocrinology 143:1182-1189, 2002.

324. Raines KB, Baker JR, Lukes YG, Wartofsky L, Burman KD. Antithyrotropin antibodies in the sera of Graves' disease patients. J Clin Endocrinol Metab 61:217-222, 1985.

325.Sikorska HM. Anti-thyroglobulin anti-idiotypic antibodies in sera of patients with Hashimoto's thyroiditis and Graves' disease. J Immunol 137:3786-3795, 1986.

326.Hara Y, Sridama V, DeGroot LJ. Auto-anti-idiotype antibody against antithyroglobulin auto-antibody in humans. J Clin Lab Immunol 26:13-20, 1988.

327.Tandon N, Jayne DRW, McGregor AM, Weetman AP. Analysis of anti-idiotypic antibodies against anti-microsomal antibodies in patients with thyroid autoimmunity. J Autoimmunity 5:557-570, 1992.

328.Hanafusa T, Chiovato L, Doniach D, Pujol-Borrell R, Russell RCG, Bottazzo GF. Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 2:1111-1115, 1983.

329.Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann F. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2:1115-1119, 1983.

330.Buscema M, Todd I, Deuss U, Hammond L, Mirakian R, Pujol-Borrell R, Bottazzo GF: Influence of tumor necrosis factor- on the modulation by interferon-α of HLA class II molecules in human thyroid cells and its effect on interferon-γ binding. J Clin Endocrinol Metab 69:433, 1989.

331.Weetman AP, Volkman DJ, Burman KD, Gerrard TL, Fauci AS. The in vitro regulation of human thyrocyte HLA-DR antigen expression. J Clin Endocrinol Metab 61:817-824, 1985.

332. Davies TF, Bermas B, Platzer M, Roman SH. T-cell sensitization to autologous thyroid cells and normal nonspecific suppressor T-cell function in Graves' disease. Clin Endocrinol 22:155-167, 1985.

333.Eguchi K, Otsubo T, Kawabe Y, Shimomura C, Ueki Y, Nakao H, Tezuka H, Matsunaga M, Fukuda T, Ishikawa N, Ito K, Nagataki S. Synergy in antigen presentation by thyroid epithelial cells and monocytes from patients with Graves' disease. Clin Exp Immunol 72:84-90, 1988.

334.Tandon N, Metcalfe RA, Barnett D, Weetman AP. Expression of the costimulatory molecule B7/BB1 in autoimmune thyroid disease. Quart J Med 87:231-236, 1994.

335.Matsuoka N, Eguchi K, Kawakami A, Tsuboi M, Nakamura H, Kimura H, Ishikawa N, Ito K, Nagataki S. Lack of B7-1/BB1 and B7-2/B70 expression on thyrocytes of patients with Graves’ disease. Delivery of costimulatory signals from bystander professional antigen-presenting cells. J Clin Endocrinol Metab 81:4137-4143, 1996.

336.Battifora M, Pesce G, Paolieri F, Fiorino N, Giordano C, Riccio M, Torre G, Olive D, Bagnasco M. B7.1 costimulatory molecule is expressed on thyroid follicular cells in Hashimoto’s thyroiditis, but not in Graves’ disease. J Clin Endocrinol Metab 83:4130-4139, 1998.

337.Lombardi G, Arnold K, Uren J, Marelli-Berg F, Hargreaves F, Inami N, Weetman AP, Lechler R. Antigen presentation by IFN-γ treated thyroid follicular cells inhibits IL-2 and supports IL-4 production by B7-dependent human T cells. Europ J Immunol 27:62-71, 1997.

338.Marelli-Berg F, Weetman AP, Frasca L, Deacock SJ, Inami N, Lombardi G, Lechler RI. Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells. J Immunol 159:5853-5861, 1997.

338a. Li YS, Kanamoto N, Hataya Y, Moriyama K, Hiratani H, Nakao K, Akamizu T. Transgenic mice producing major histocompatibility complex class II molecules on thyroid cells do not develop apparent thyroid autoimmunity. J Clin Endocrinol Metab 145: 2524- 2530, 2004.

339.Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Intense expression of the B7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescents. J Clin Endocrinol Metab 87:4391-4397, 2002.

340.Fisfalen M-E, Franklin WA, DeGroot LJ, Cajulis RS, Soltani K, Ryan M, Jones N. Expression of HLA-ABC and -DR antigens in thyroid neoplasia and correlation with mononuclear leukocyte infiltration. J Endocrinol Invest 13:41-48, 1990.

341.Cohen SB, Dijkstra CD, Weetman AP. Sequential analysis of experimental autoimmune thyroiditis induced by neonatal thymectomy in the Buffalo strain rat. Cell Immunol 114:126-136, 1988.

342.Leclere J, Bene MC, Duprez A, Faure G, Thomas JL, Vignaud JM, Burlet C. Behavior of thyroid tissue from patients with Graves' disease in nude mice. J Clin Endocrinol Metab 59:175, 1984.

343.Sospedra M, Obiols G, Babi LFS, Tolosa E, Vargas F, Roura-Mir C, Lucas-Martin A, Ercilla G, Pujol-Borrell R. Hyperinducibility of HLA class II expression of thyroid follicular cells from Graves’ disease. J Immunol 154:4213-4222, 1995.

344.Wong GWK, Cheng PS. Increasing incidence of childhood Graves’ disease in Hong Kong: A follow-up study. Clin Endocrinol 54:547-550, 2001.

345.Kaplan MM. Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells. N Engl J Med 318:1557-1563, 1988.

346.Gilquin J, Viard J-P, Jubault , Sert C, Kazatchkine MD. Delayed occurrence of Graves’ disease after immune restoration with HAART. Lancet 352:1907-1908, 1998.

347.Durelli L, Ferrero B, Oggero A, Verdun E, Ghezzi A, Montanari E, Zaffaroni M and the Betaferon Safety Trial Study Group. Thyroid function and autoimmunity during interferon β-1b treatment: A multicenter prospective study. J Clin Endocrinol Metab 86:3525-3532, 2001.

348. Craccio N, Dradano A, Manfredonia F et al. Long-term follow-up of 106 multiple sclerosis patients undergoing interferon-β 1a or 1b therapy : predictive factors of thyroid disease development and duration. J Clin Endocrinol Metab 90:4133-4137, 2005.

349.Hidaka Y, Amino N, Iwatani Y, Itoh E, Matsunaga M, Tamaki H. Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves' disease. J Clin Endocrinol Metab 77:1667-1670, 1993.

350.Yamada T, Sato A, Komiya I, Nishimori T, Ito Y, Terao A, Eto S, Tanaka Y. An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves’ disease. J Clin Endocrinol Metab 85:2775-2778, 2000.

351.Bartalena L, Bogazzi F, Tanda ML, Manetti L, Dell’Unto E, Martino E. Cigarette smoking and the thyroid. Europ J Endocrinol 133:507-512, 1995.

352.Rumold R, Jyrala M, Diaz-Sanchez D. Secondhand smoke induces allergic sensitization in mice. J Immunol 167:4765-4770, 2001.

353. Belin RM, Astor BC, Powe NR, Ladenson PW. Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 89: 6077-6086, 2004.

354.Papanastasiou L, Alevizaki M, Piperingos G, Mantzos E, Tseleni-Balafouta S, Koutras DA. The effect of iodine administration on the development of thyroid autoimmunity in patients with nontoxic goiter. Thyroid 10:493-497, 2000.

355. Zois C, Stavrou I, Svarna E, Seferiadis K, Tsatsoulis A.Natural course of autoimmune thyroiditis after elimination of iodine deficiency in northwestern Greece. Thyroid. 16: 289-93, 2006.

356. McLachlan SM, Braley-Mullen H, Chen CR, Aliesky H, Pichurin PN, Rapoport B. Dissociation between iodide-induced thyroiditis and antibody-mediated hyperthyroidism in NOD.H-2h4 mice. Endocrinol 146: 294-300, 2005.

356a. Turker O, Kumanlioglu K, Karapolat I, Dogan I.Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses. J Endocrinol. 190:151-6, 2006.

357.Chiovato L, Pinchera A. Stressful life events and Graves’ disease. Europ J Endocrinol 134:680-682, 1996.

358. Streider TGA, Prummel MF, Tijssen JCP, Brosschot JF, Wiersinga W. Stress is not associated wirthh thyroid peroxidase autoantibodies in euthyroid women. Brain Behav Immun 19: 203-206, 2004.

359.Steinman L. Elaborate interactions between the immune and nervous systems. Nature Immunol 5:575-581, 2004.

360.Saint-Mezard P, Chavagnac C, Bosset S, Ionescu M, Peyron E, Kaiserlian D, Nicolas J-F, Bérard F. Psychological stress exerts an adjuvant effect on skin dendritic cell functions in vivo. J Immunol 171:4073-4080, 2003.

361.McGregor AM, Ibbertson HK, Smith BR, Hall R. Carbimazole and autoantibody synthesis in Hashimoto's thyroiditis. Brit Med J 281:968-969, 1980.

361.Wenzel KW, Lente JR. Similar effects of thionamide drugs and perchlorate on thyroid-stimulating immunoglobulins in Graves' disease: evidence against an immunosuppressive action of thionamide drugs. J Clin Endocrinol Metab 58:62- 69, 1984.

362.Weetman AP, Holt ME, Campbell AK, Hall R, McGregor AM. Methimazole and generation of oxygen radicals by monocytes: potential role in immunosuppression. Brit Med J 288:518-520, 1984.

363.Mitsiades N, Poulaki V, Tseleni-Balafouta S, Chrousos GP, Koutras DA. Fas ligand expression in thyroid follicular cells from patients with thionamide-treated Graves’ disease. Thyroid 10:527-532, 2000.

364.Komiya I, Yamada T, Sato A, Kouki T, Nishimori T, Takasu N. Remission and recurrence of hyperthyroid Graves’ disease during and after methimazole treatment when assessed by IgE and interleukin 13. J Clin Endocrinol Metab 86:3540-3544, 2001.

365. Crile G Jr. The treatment of diseases of the thyroid gland. Ann R Coll Surg Engl 14:158, 1954.

366. Hubble D. The diagnosis and treatment of auto-immunizing thyroiditis. Scott Med J 4:55, 1959.

367. Bastenie PA. Contribution a l'etiologie du myxodeme spontane de l'adulte. Bull Acad Med Belg 9:179, 1944.

368. Douglass RC, Jacobson SD. Pathologic changes in adult myxedema. Survey of necropsies. J Clin Endocrinol Metab 17:1354, 1957.

369.Owen SG, Smart GA. Thyroid antibodies in myxedema. Lancet 2:1034, 1958.

370.Drexhage HA. Autoimmunity and thyroid growth. Where do we stand? European Journal of Immunology 135:39-45, 1996.

371. Buchanan WW, Alexander WD, Crooks J, Koutras DA, Wayne EJ, Anderson JR, Goudie RB. Association of thyrotoxicosis and autoimmune thyroiditis. Br Med J 1:843, 1961.

372. Fatourechi V, McConahey WM, Woolner LB. Hyperthyroidism associated with histologic Hashimoto's thyroiditis. Mayo Clin Proc 46:682, 1971.

373. Whitesell FB, Black BM. Statistical study of clinical significance of lymphocytic and fibrocytic replacements in hyperplastic thyroid gland. J Clin Endocrinol 9:1202, 1949.

374.Blagg CR. Antibodies to thyroglobulin in patients with thyrotoxicosis treated with radioactive iodine. Lancet 2:1364, 1960.

375.Eason J. Correlation of Graves' disease and thyroiditis. Edinburgh Med J 35:169, 1928.

376.Tonacchera M, Van Sande J, Parma J, Duprez L, Cetani F, Costagliola S, Dumont JE, Vassart G. TSH receptor and disease. Clin Endocrinol 44:621-633, 1996.

377.Prabhakar BS, Fan J-L, Seetharamaiah GS. Thyrotropin-receptor-mediated diseases: A paradigm for receptor autoimmunity. Immunol Today 18:437-442, 1997.

378.Di Cerbo A, Di Paola R, Bonati M, Zingrillo M, De Filippis V, Corda D. Subgroups of Graves’ patients identified on the basis of the biochemical activities of their immunoglobulins. J Clin Endocrinol Metab 80:2785-2790, 1995.

379.Kohn LD, Suzuki K, Hoffman WH, Tombaccini D, Marcocci C, Shimojo N, Watanabe Y, Amino N, Cho BY, Kohno Y, Hirai A, Tahara K. Characterization of monoclonal thyroid-stimulating and thyrotropin binding-inhibiting autoantibodies from a Hashimoto’s patient whose children had intrauterine and neonatal thyroid disease. J Clin Endocrinol Metab 82:3998-4009, 1997.

380.Kung AWC, Jones BM. A change from stimulatory to blocking antibody activity in Graves’ disease during pregnancy. J Clin Endocrinol Metab 83:514-518, 1998.

381. DeGroot LJ, Hoye K, Refetoff S, Van Herle AJ, Asteris GT, Rochman H. Serum antigens and antibodies in the diagnosis of thyroid cancer. J Clin Endocrinol Metab 45:1220, 1977.

382. DeGroot LJ, Paloyan E. Thyroid carcinoma and radiation. A Chicago endemic. J Amer Med Assn 225:487, 1973.

383. Woolner LB, McConahey WM, Beahrs OH. Struma lymphomatosa and related thyroidal disorders. J Clin Endocrinol Metab 19:53, 1959.

384. Holmes HB, Kreutner A, O'Brien PH. Hashimoto's thyroiditis. Its relationship to other thyroid diseases. Surg Gynecol Obstet 144:887, 1977.

385. Matsuzuka F, Miyauchi A, Katayama S, Narabayashi I, Ikeda H, Kuma K, Sugawara M. Clinical aspects of primary thyroid lymphoma: Diagnosis and treatment based on our experience of 119 cases. Thyroid 3:93-99, 1993.

386. Dailey ME, Lindsay S, Skahen R. Relation of thyroid neoplasms to Hashimoto's disease of the thyroid gland. Arch Surg 70:291, 1955.

387. Gribetz D, Talbot NB, Crawford JD. Goiter due to lymphocytic thyroiditis (Hashimoto's struma): Its occurrence in preadolescent and adolescent girls. N Engl J Med 250:555, 1954.

388.Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med 348:2646-2655, 2003.

389. Pratt DE, Kaberlein G, Dudkiewicz A, Karande V, Gleicher N. The association of antithyroid antibodies in euthyroid nonpregnant women with recurrent first trimester abortions in the next pregnancy. Fertil Steril, 60:1001-1005, 1993.

390.Poppe K, Glinoer D, Tournaye H, Devroey P, van Steirteghem A, Kaufman L, Velkeniers B. Assisted reproduction and thyroid autoimmunity: an unfortunate combination? J Clin Endocrinol Metab 88:4149-4152, 2003.

391.Giani C, Fierabracci P, Bonacci R, Gigliotti A, Campani D, De Negri F, Cecchetti D, Martino E, Pinchera A. Relationship between breast cancer and thyroid disease: Relevance of autoimmune thyroid disorders in breast malignancy. J Clin Endocrinol Metab 81:990-994, 1996.

392.Smyth PPA, Shering SG, Kilbane MT, Murray MJ, McDermott EWM, Smith DF, O’Higgins NJ. Serum thyroid peroxidase autoantibodies, thyroid volume, and outcome in breast carcinoma. J Clin Endocrinol Metab 83:2711-2716, 1998.

393.Pop VJ, Maartens LH, Leusink G, Van Son MJ, Knottnerus AA, Ward AM, Metcalfe R, Weetman AP. Are autoimmune thyroid dysfunction and depression related? J Clin Endocrinol Metab 83:3194-3197, 1998.