TOPIC: TSH receptor Title: Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Authors: Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CT, Raaka BM, & Gershengorn MC . Reference: Proc. Natl. Acad. […]

TOPIC: Genes involved in early thyroid development Title: Expression of Islet1 in thyroid deve buy cheap kamagra lopment related to budding, migration, and fusion of primordia. Authors: Westerlund J, Andersson L, Carlsson T, Zoppoli P, Fagman H, & Nilsson M. Reference: Developmental Dynamics 237, 3820-3829, 2008 Summary Background The thyroid is populated by two endocrine […]

TOPIC: Thyroid development Title: Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Authors: : Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, & Rohr KB. Reference: Development 134: 2871-2879, 2007 (doi:10.1242/dev.02872) Summary Background In all vertebrates, the thyroid gland develops from the ventral […]

Topic: MECHANISM OF TSH RECEPTOR ACTIVATION Title: Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity. Authors: Chen C-R, McLachlan SM, & Rapoport B. Reference: Endocrinology, 2007 (First published ahead of print on February 1, 2007 as doi:10.1210/en.2006-1754) Summary Background Thyrotropin (TSH) binding to the TSH receptor (TSHR) induces thyrocyte […]