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Figure 4. Consensus thyroid response element (TRE). Studies of TRE’s in many different promoters has allowed the derivation of a “consensus” TRE comprised of a direct repeat of the hexameric sequence, AGGTCA, spaced by four nucleotides (n). Of note, there is considerable diversity in the sequences of half-sites, orientation of half-sites, and bases that form the spacers between half-sites (see text).