TDM-ch3d-fig006

Figure 6. Role of corepressors and coactivators in the control of T3-regulated genes. In the absence of T3, the RXR-TR heterodimer recruits corepressors (CoR), which in turn, assemble additional components of a repressor complex that includes histone deacetylase (HDAC). Deacetylation of histones induce transcriptional repression. In the presence of T3, the corepressor complex dissociates and coactivators (CoA) bind to TR. The coactivator complex can include steroid receptor co-activators (SRCs)/p160, CREB-binding protein (CBP), p300/CBP associated factor (P/CAF), and proteins with histone acetyltransferase (HAT) activity. Vitamin D receptor interacting protein/TR associated protein (DRIP/TRAP) complex can also interact with liganded TR, and may cycle with SRC/p160 complex. The general transcription factors (GTFs) are also indicated.