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Fig. 1-13. Linear representation of the TSH receptor. Sequences common to all rhodopsin-like G protein-coupled receptors and sequences specific to the glycoprotein hormone receptor gene family are both implicated in activation of the TSH receptor. Key residues are indicated (red dots) as well as conserved motifs: SO3 — stands for postranslational sulfation of the indicated tyrosine residues (693). The black boxes stand for transmembrane helices and I1-I3, E1-E3, for intracellular and extracellular loops, respectively; LRR, leucine-rich repeats.