Archives for February, 2008

Local expression of TR’2 & cone photoreceptor differentiation

TOPIC: Patterning of retinal cone photoreceptor development Title: NeuroD1 regulates expression of thyroid hormone receptor '2 and cone opsins in the developing mouse retina. Authors: Liu H, Etter P, Hayes S, Jones I, Nelson B, Hartman B, Forrest D, & Reh T. Reference: The Journal of Neuroscience, 28: 749-756, 2008 Summary Objective The correct patterning […]

Estimation vs measurement of serum free T4 in the pregnant state

TOPIC: Free T4 measurements during pregnancy Title: Tandem mass spectrometry improves the accuracy of free T4 measurements during pregnancy. Authors: Kahric-Janicic N, Soldin SJ, Soldin OP, West T, Gu J, & Jonklaas J. Reference: Thyroid 17: 303-311, 2007 Summary Objective The aim of the study was to compare a new tandem mass spectrometric (LC/MS/MS) method […]

Role of D3 in the development of the hypothalamus-pituitary-thyroid axis

TOPIC: Thyroid hormone metabolism & action Title: Type 2 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis. Authors: Hernandez A, Martinez ME, Liao XH, Van Sande J, Refetoff S, Galton VA, & St Germain DL. Reference: Endocrinology 148: 5680-5687, 2007 Summary Background The type 3 deiodinase (D3) is a selenoenzyme […]