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Archives for March, 2009

Graves disease in children

TOPIC: Predictors of relapse in pediatric Graves’ disease Title: Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment. Authors: Kaguelidou F, Alberti C, Castanet M, Guitteny M-A, Czernichow P, Léger J (the French childhood Graves’ disease study group) Reference: Journal of Clinical Endocrinology & Metabolism93: 3817–3826, 2008 There is debate about […]

Thyroid hormone transport into the brain

TOPIC: Role of membrane transporters of thyroid hormone on their transfer into the brain Title: Expression of the thyroid hormone transporter MCT8 (SLC16A2) and AOTP14 (SLC01C1) at the blood-brain barrier. Authors: Roberts LM, Woodford K, Zhou M, Black DS, et al. Reference: Endocrinology 149: 6251-6261, 2008 Summary Background Thyroid hormones require transport across cell membranes […]

Thyroid autoimmunity

TOPIC: Use of Pendrin antibody measurement in AITD Title: Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. Authors: Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, et al. Reference: Journal of Clinical Endocrinology & Metabolism94: 442-448, 2009 Context Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux […]

Thyroxine treatment in pregnant women with hypothyroidism

TOPIC: Treatment of pregnant hypothyroid women Title: The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidism. Authors: Loh JA, Wartofsky L, Jonklaas J, & Burman KD. Reference: Thyroid 19 (3): 269-275, 2009 Summary Background In the United States, many women are on thyroid hormone replacement for hypothyroidism […]

Thyroxine monotherapy restores serum T3 levels

TOPIC: Thyroxine replacement therapy Title: Serum T3 levels in athyreotic individuals during thyroxine therapy. Authors: Jonklaas J, Davidson B, Bhagat S, & Soldin SJ. Reference: Journal of the American Medical Association 20: 769-777, 2008 Summary Background Some hypothyroid patients on thyroxine (LT4) therapy report a variety of symptoms including poor mood, lethargy, and cognitive impairment […]