TOPIC: Use of Pendrin antibody measurement in AITD Title: Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. Authors: Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, et al. Reference: Journal of Clinical Endocrinology & Metabolism94: 442-448, 2009 Context Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux […]

TOPIC: Treatment of pregnant hypothyroid women Title: The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidism. Authors: Loh JA, Wartofsky L, Jonklaas J, & Burman KD. Reference: Thyroid 19 (3): 269-275, 2009 Summary Background In the United States, many women are on thyroid hormone replacement for hypothyroidism […]

TOPIC: Thyroxine replacement therapy Title: Serum T3 levels in athyreotic individuals during thyroxine therapy. Authors: Jonklaas J, Davidson B, Bhagat S, & Soldin SJ. Reference: Journal of the American Medical Association 20: 769-777, 2008 Summary Background Some hypothyroid patients on thyroxine (LT4) therapy report a variety of symptoms including poor mood, lethargy, and cognitive impairment […]

TOPIC: Tg-Ab measurements for prediction of recurrence in thyroid cancer Title: The prevalence of transient change of serum thyroglobulin antibody levels is useful for prediction of clinical recurrence in thyroglobulin-negative patients with differentiated thyroid carcinoma Authors: Kim WG , Yoon JH, Kim WB , Kim TY , Kim EY , Kim JM , Ryu JS […]

TOPIC: Thyroid hormone receptor Title: Thyroid hormone receptor alpha1 acts as a potent suppressor of tumor invasiveness and metastasis. Authors: Martinez-Iglesias O, Garcia-Silva S, Tenbaum SP, Regadera J, Larcher F, Paramio JM, Vennstrom B, & Aranda A. Reference: Cancer Research 69: 501-509, 2009 Summary Background Loss of thyroid hormone receptors (TR) is a common feature […]