TOPIC: Free T4 measurements during pregnancy Title: Tandem mass spectrometry improves the accuracy of free T4 measurements during pregnancy. Authors: Kahric-Janicic N, Soldin SJ, Soldin OP, West T, Gu J, & Jonklaas J. Reference: Thyroid 17: 303-311, 2007 Summary Objective The aim of the study was to compare a new tandem mass spectrometric (LC/MS/MS) method […]

TOPIC: Thyroid hormone metabolism & action Title: Type 2 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis. Authors: Hernandez A, Martinez ME, Liao XH, Van Sande J, Refetoff S, Galton VA, & St Germain DL. Reference: Endocrinology 148: 5680-5687, 2007 Summary Background The type 3 deiodinase (D3) is a selenoenzyme […]

TOPIC: Thyroid development Title: Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Authors: : Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, & Rohr KB. Reference: Development 134: 2871-2879, 2007 (doi:10.1242/dev.02872) Summary Background In all vertebrates, the thyroid gland develops from the ventral […]

TOPIC: D yshormonogenesis due to mutations in DUOXA2 gene Title: Biallelic inactivation of the dual oxidase maturation factor 2 ( DUOXA2 ) gene as a novel cause of congenital hypothyroidism. Authors: Zamproni I, Grasberger H, Cortinovis F, Vigone MC, Chiumello G, Mora S, Onigata K, Fugazzola L, Refetoff S, Persani L, & Weber G. Reference: […]

TOPIC: Graves' orbitopathy Title: Modulation of expression of somatostatin receptor subtypes in Graves' ophthalmopathy orbits: relevance to novel analogues Authors: Cozma I, Zhang L, Uddin J, Lane C, Rees A, & Ludgate M Reference: Am J Physiol Endocrinol Metab 293: E1630-E1635, 2007 (ahead of print) Summary Background Treatment of Graves'orbitopathy (GO) with two somatostatin analogs, […]