TOPIC: A ntithyroid drugs for treatment of hyperthyroidism due to Graves- disease Title: Comparison of methimazole & propylthiouracil in patients with hyperthyroidism caused by Graves- disease. Authors: Nakamura H, Noh JY, Itoh K, Fukata S, Miyauchi A, Hamada N (and the working group of the Japan Thyroid Association for the guideline of the treatment of […]

TOPIC: New genes involved in thyroid disease Title: A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Authors: Risheg H, Graham JM Jr, Clark RD, Rogers RC, Opitz JM, Moeschler JB, Peiffer AP, May M, Joseph SM, Jones JR, Stevenson RE, Schwartz CE, & Friez MJ. Reference: Nature Genetics 39: 451-453, 2007 Summary […]

Topic: New genes in the pathogenesis of thyroid disease Title: The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Authors: Fagman H, Liao J, Westerlund J, Andersson L, Morrow BE, & Nilsson M. Reference: Human Molecular Genetics 16: 276-285, 2007 Summary Background Thyroid dysgenesis is the major cause of congenital hypothyroidism in […]

Topic: Thyroid hormone metabolism and action Title: Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytes. Authors: Hernandez A, Garcia B, & Obregon MJ. Reference: Endocrinology, May 17, 2007 [Epub ahead of print] Summary Background Active thyroid hormones are critical for the differentiation and function of brown adipose […]

Topic: V itiligo: a role for the innate immune system? Title- NALP1 in vitiligo-associated multiple autoimmune disease. Authors: Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, & Spritz RA. Reference: New England Journal of Medicine 356: 1216-1225, 2007 Summary Background Autoimmune thyroid disease is the commonest of a group […]