QUESTION–A young 23 years old girl diagnosed to have Functional ectopic lingual thyroid with Overt Hypothyroidism with absence of tracer uptake in the thyroid region on Tc99 scintigraphy in the year 2004. Since she has been on 125mcg Thyroxine replacement. Her TSH was 19uIU/ml in Feb 2013 and on proper dose titration as now TSH reached to [...]
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Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 british birth cohort study.Ong KK, Kuh D, Pierce M, Franklyn JA. J Clin Endocrinol Metab. 2013 Apr;98(4):1435-42. doi: 10.1210/jc.2012-3761 Complex bidirectional relationships have been described between body weight, thyroid function, and risk of thyroid disorders, including thyroid autoimmunity. We used a life-course approach [...]
Low- or high-dose radioiodine remnant ablation for differentiated thyroid carcinoma: a meta-analysis. Cheng W, Ma C, Fu H, Li J, Chen S, Wu S, Wang H. J Clin Endocrinol Metab. 2013 Apr;98(4):1353-60. doi: 10.1210/jc.2012-3682. There is uncertainty over the dose of (131)I required for thyroid remnant ablation.: The aim of this study was to assess [...]
NO-Generic and brand-name L-thyroxine are not bioequivalent for children with severe congenital hypothyroidism.Carswell JM, Gordon JH, Popovsky E, Hale A, Brown RS. J Clin Endocrinol Metab. 2013 Feb;98(2):610-7. doi: 10.1210/jc.2012-3125. In the United States, generic substitution of levothyroxine (l-T(4)) by pharmacists is permitted if the formulations are deemed to be bioequivalent by the Federal Drug [...]
The noninvestigational use of tyrosine kinase inhibitors in thyroid cancer: establishing a standard for patient safety and monitoring.Carhill AA, Cabanillas ME, Jimenez C, Waguespack SG, Habra MA, Hu M, Ying A, Vassilopoulou-Sellin R, Gagel RF, Sherman SI, Busaidy NL. J Clin Endocrinol Metab. 2013 Jan;98(1):31-42 The increasing use of tyrosine kinase inhibitor therapy outside of [...]
RAI ABLATION WITH BRAF+ 1.2CM NODE-NEGATIVE PAPILLARY CANCER? 22Jan2013 QUESTION- your opinion on this patient please. 34 yo anesthesiologist noted a midline thyroid nodule 1 month ago, no hx of irradiation to head and neck. us revealed a 1.2 cm hypoechoic nodule at jx of isthmus and right lobe, fna highly suspicious for mjalignancy, 2nd [...]
Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. J Clin Endocrinol Metab. 2012 Dec;97(12):4464-72, Karakosta P, Alegakis D, Georgiou V, Roumeliotaki T, F Buy cheap Levitra online thenou E, Vassilaki M, Boumpas D, Castanas E, Kogevinas M, Chatzi L. Maternal thyroid dysfunction, especially in [...]
Association and Predictive Accuracy of High TSH Serum Levels in First Trimester and Adverse Pregnancy Outcomes. Sc sale viagra hneuer FJ, Nassar N, Tasevski V, Morris JM, Roberts CL. J Clin Endocrinol Metab. 2012 Sep;97(9):3115-22 francisco.schneuer@sydney.edu.au. 17 Oct 2012 High serum levels of TSH have been associated with adverse pregnancy outcomes by some studies, and [...]
Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges.17 Oct 2012 Persani L. luca.persani viagra online best price @unimi.it. J Clin Endocrinol Metab. 2012 Sep;97(9):3068-78. Central hypothyroidism (CH) is a particular hypothyroid condition due to an insufficient stimulation by TSH of an otherwise normal thyroid gland. This condition raises several challenges for clinicians; therefore, a review of [...]
Alexander, EK, Kennedy GC,
Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline.
. NEW CLINICAL OBSERVATIONS REGARDING THYROID CANCER The most recent issue of JCEM is filled with interesting studies on thyroid cancer. Balasubramaniam S, Ron E, Gridley G, Schneider AB, Brenner AV.(
Biondi B, Wartofsky L. Combination treatment with t4 and t3: toward personalized replacement therapy in hypothyroidism? J Clin Endocrinol Metab. 2012 Jul;97(7):2256-71. Levothyroxine therapy is the traditional lifelong replacement therapy for hypothyroid patients. Over the last several years, new evidence has led clinicians to evaluate the option of combined T(3) and T(4) treatment to improve [...]
QUESTION-Dear Endotext.org,–Thank you very much for the free expert information you provide for practioners everywhere. I have a case I would like to run past an expert. A 19 y.o. female patient was sent to buy generic cialis online our endocrinology offices from her primary care provider/gynecologist due to abnormal thyroid function tests. She has [...]
A stimulatory thyrotropin receptor antibody enhances hyaluronic Acid synthesis in graves’ orbital fibroblasts: inhibition by an igf-I receptor blocking antibody.