TOPIC: A new type of mutation in the TSH receptor Title: A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca 2+ cascade mediates TSH action on thyroid hormone synthesis. Authors: Grasberger H , Van Sande J , Hag-Dahood MA , Tenenbaum-Rakover Y , & Refetoff S. Reference: Journal of Clinical […]

TOPIC: Knowledge concerning thyroid diseases and pregnancy Title: Thyroid disease and pregnancy: degrees of knowledge. Authors: Rinaldi MD & Stagnaro-Green AS. Reference: Thyroid 17: 747-753, 2007 Summary Objective The literature on the impact of thyroid abnormalities on pregnancy and the postpartum has expanded rapidly over the last two decades. Objective of present study was to […]

TOPIC: Graves-orbitopathy Title: Patients with severe Graves- ophthalmopathy have a higher risk of relapsing hyperthyroidism and are unlikely to remain in remission. Authors: Ecktsein AK, Lax H, Losch C, Glowacka D, Plicht M, Mann K, Esser J & Morgenthaler NG. Reference: Clinical Endocrinology 67: 607-612, 2007 Summary Background Graves- hyperthyroidism and orbitopathy (GO) are frequently […]

TOPIC: Hormone determinations in wash-out fluid from FNA Title: Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma. Authors: Boi F, Maurelli I, Pinna G, Atzeni F, Piga M, Lai ML, & Mariotti S. Reference: Journal of Clinical Endocrinology & Metabolism 92: 2115-2118, […]

Topic: DNA damage at the origin of cancer Title: Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice. Authors: Maier J, van Steeg H, van Oostrom C, Paschke R, Weiss RE & Krohn K. Reference: Biochimica Biophysica Acta 1773: 990-999, 2007 Summary Background Stimulation of the thyroid […]

Topic: Effects of acute bexarotene administration on TSH secretion in normal subjects Title: Single-Dose Rexinoid rapidly and specifically suppresses serum thyrotropin (TSH) in normal subjects. Authors: Golden WM, Weber KB, Hernandez TL, Sherman SI, Woodmansee WW, & Haugen BR. Reference: Journal of Clinical Endocrinology & Metabolism 92: 124-130, 2007 Summary Background Retinoid X receptor agonists […]

TOPIC: Increased risk of cardiovascular & cancer deaths from radioiodine treatment for hyperthyroidism Title: Increased cardiovascular and cancer mortality after radioiodine treatment of hyperthyroidism. Authors: Metso S, Jaatinen P, Huhtala H, Auvinen A, Oksala H, & Salmi J. Reference: Journal of Clinical Endocrinology & Metabolism 92: 2190-2196, 2007 Summary Background Although patients treated with radioiodine […]

TOPIC: Potential role for the IGF-1 receptor on T cells in Graves- disease Title: Aberrant expressions of the insulin-like growth factor-1 receptor by T cells from patients with Graves- disease may carry functional consequences for disease pathogenesis. Authors: Douglas RS, Gianoukakis AG, Kamat S, & Smith TJ. Reference: Journal of Immunology 178: 3281-3287, 2007 Summary […]

TOPIC: Excessive iodine intake and the risk of thyroid autoimmune disease Title: Effect of iodine intake on thyroid diseases in China. Authors: Teng W, Shan Z, Teng X, Guan H, et al. Reference: New England Journal of Medicine 354: 2783-2793, 2006 Summary Background Normal thyroid function requires iodine to produce thyroid hormones. Both low (i.e. […]

TOPIC: A ntithyroid drugs for treatment of hyperthyroidism due to Graves- disease Title: Comparison of methimazole & propylthiouracil in patients with hyperthyroidism caused by Graves- disease. Authors: Nakamura H, Noh JY, Itoh K, Fukata S, Miyauchi A, Hamada N (and the working group of the Japan Thyroid Association for the guideline of the treatment of […]

TOPIC: New genes involved in thyroid disease Title: A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Authors: Risheg H, Graham JM Jr, Clark RD, Rogers RC, Opitz JM, Moeschler JB, Peiffer AP, May M, Joseph SM, Jones JR, Stevenson RE, Schwartz CE, & Friez MJ. Reference: Nature Genetics 39: 451-453, 2007 Summary […]

Topic: New genes in the pathogenesis of thyroid disease Title: The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Authors: Fagman H, Liao J, Westerlund J, Andersson L, Morrow BE, & Nilsson M. Reference: Human Molecular Genetics 16: 276-285, 2007 Summary Background Thyroid dysgenesis is the major cause of congenital hypothyroidism in […]

Topic: Thyroid hormone metabolism and action Title: Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytes. Authors: Hernandez A, Garcia B, & Obregon MJ. Reference: Endocrinology, May 17, 2007 [Epub ahead of print] Summary Background Active thyroid hormones are critical for the differentiation and function of brown adipose […]

Topic: V itiligo: a role for the innate immune system? Title- NALP1 in vitiligo-associated multiple autoimmune disease. Authors: Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, & Spritz RA. Reference: New England Journal of Medicine 356: 1216-1225, 2007 Summary Background Autoimmune thyroid disease is the commonest of a group […]

Topic: Mutations in congenital hypothyroidism Title -Congenital hypothyroidism, dwarfism and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox 2. Authors: Johnson KR, Marden CC, Ward-Bailey P, Gagnon LH, Bronson RT, & Donahue LR Reference: Molecular Endocrinology (first published ahead of print April 17, 2007) Summary Background The mouse […]

Topic: Sensitive Tg assays and recombinant human TSH (rhTSH) Title: Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in the follow-up of thyroid cancer patients. Authors: Smallridge RC , Meek SE , Morgan MA , Gates GS , Fox TP , Grebe S , & Fatourechi V Reference: Journal […]

Topic: Regulation of Expression of Na + /I – Symporter Title: PTTG and PBF repress the human sodium iodide symporter. Authors: Boelaert K, Smith VE, Stratford AL, Kogai T, Tannahill LA, Watkinson JC, Eggo MC, Franklyn JA, & McCabe CJ. Reference: Oncogene (advance online publication; 5 February 2007); doi: 10.1038/sj.onc.1210221 Summary Background The ability of […]

Topic: RhTSH & CONGENITAL HYPOTHYROIDISM Title: Recombinant thyrotropin in the diagnosis of congenital hypothyroidism. Authors: Tiosano D, Even L, Orr ZS, & Hochberg Z Reference: Journal of Clinical Endocrinology & Metabolism, 92: 1424-1437, 2007 Summary Background A modern approach to congenital hypothyroidism requires a definitive diagnosis of the underlying mechanisms; this can be achieved within […]

Topic: DOPPLER ULTRASONOGRAPHY & HYPERTHYROIDISM Title: Color Flow Doppler Sonography for the Etiologic Diagnosis of Hyperthyroidism. Authors: Erdogan MF, Anil C, Cesur M, Baskal N, and Erdogan G. Reference: Thyroid 17: 223-228, 2007 Summary Background Color flow Doppler sonography is gaining importance for the functional evaluation of thyroid disorders. Purpose The objective of this study […]

Topic: MECHANISM OF TSH RECEPTOR ACTIVATION Title: Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity. Authors: Chen C-R, McLachlan SM, & Rapoport B. Reference: Endocrinology, 2007 (First published ahead of print on February 1, 2007 as doi:10.1210/en.2006-1754) Summary Background Thyrotropin (TSH) binding to the TSH receptor (TSHR) induces thyrocyte […]

Topic: NON-THYROIDAL ILLNESS SYNDROME Title: Frequency and outcome of patients with non-thyroidal illness syndrome in a medical intensive care unit Authors: Plikat K , Langgartner J , Buettner R , Bollheimer LC , Woenckhaus U , Scholmerich J , Wrede CE. Reference: Metabolism 56: 239-244, 2007 Summary Background Acute and chronic critical conditions are associated […]

Topic: GRAVES- ORBITOPATHY Title: Randomized, double-blind, placebo-controlled trial of long-acting release octreotide for treatment of Graves- ophthalmopathy Authors: Stan MN, Garrity JA, Bradley EA, Woog JJ, Bahn MM, Brennan MD, Bryant SC, Achenbach SJ, & Bahn RS. Reference: Journal of Clinical Endocrinology and Metabolism 91: 4817-4824, 2006 Summary Background Somatostatin analogs have been proposed as […]

Topic: GOITROUS CONGENITAL HYPOTHYROIDISM Title -Goitrous congenital hypothyroidism in a twin pregnancy causing respiratory obstruction at birth: implications for management. Authors: Reynolds BC, Simpson JH, Macara L, Watt AJB, Kubba H, Donaldson MDC, & Pohlenz J. Reference: Acta Paediatrica 95: 1345-1348, 2006 Summary Objectives Report on a twin pregnancy complicated by fetal goitrous hypothyroidism secondary […]

Topic: THYROID AND PREGNANCY Title: Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding? Authors: Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S, Bilous R. Reference: Journal of Clinical Endocrinology and Metabolism 92: 203-207, 2007 Summary Background Maternal subclinical hypothyroidism in pregnancy is common (about 2.5%). […]

Topic: THYROID CANCER Title: Trend in thyroid carcinoma size, age at diagnosis, and histology in a retrospective study of 500 cases diagnosed over 20 years. Authors: Trimboli P, Graziano FM, Marzullo A, Ruggieri M, Calvanese A, Piccirilli F, Cavaliere R, Fumarola A, D-Armiento M. Reference: Thyroid 16: 1151-1155, 2006 Summary Background Recently, several reports have […]