Real-time elastosonography: useful tool for refining the presurgical diagnosis in thyroid nodules with indeterminate or nondiagnostic cytology. Rago T , Scutari M , Santini F , Loiacono V , Piaggi P , Di Coscio G , Basolo F , Berti P , Pinchera A , Vitti P . J Clin Endocrinol Metab. 2010 Dec;95(12):5274-80. Epub […]

Thyroid cancer recurrence in patients clinically free of disease with undetectable or very low serum thyroglobulin values. Kloos RT J Clin Endocrinol Metab. 2010 Dec;95(12):5241-8. Epub One hundred seven patients had initial thyroid cancer surgery and subsequent remnant radioiodine ablation. Patients underwent recombinant human TSH (rhTSH)-mediated diagnostic whole-body scan and rhTSH-stimulated thyroglobulin (Tg) measurement before […]

Selenium and the thyroid: a close-knit connection. Duntas LH J Clin Endocrinol Metab. 2010 Dec;95(12):5180-8. Epub 2010 Sep 1. The recent recognition that the essential trace element selenium is incorporated as selenocysteine in all three deiodinases has decisively confirmed the clear-cut link between selenium and thyroid function. It has additionally been established that the thyroid […]

Approach to management of the patient with primary or secondary intrathoracic goiter. Hegedüs L , Bonnema SJ J Clin Endocrinol Metab. 2010 Dec;95(12):5155-62. Intrathoracic (substernal) goiter, depending on definition, is seen in up to 45% of all patients operated for goiter. It can either be primary (ectopic thyroid tissue detached from a cervical thyroid mass), […]

J Clin Endocrinol Metab. 2010 Sep;95(9):E54-7. Epub 2010 Jun 30. Troch M , Koperek O , Scheuba C , Dieckmann K , Hoffmann M , Niederle B , Raderer M Anaplastic thyroid carcinoma (ATC) is a rare but aggressive solid tumor with a very short survival time even with multimodality treatment. In view of in […]

JCEM 2010, 95(9):4197-4205 Basolo et al Evaluation of the degree of neoplastic infiltration beyond the thyroid capsule remains a unique parameter that can be evaluated by histopathological examination to label a papillary thyroid carcinoma (PTC) of 20 mm or less in size as a pT1 or pT3 tumor. We correlated the BRAF V600E mutation with […]

The Birmingham Elderly Thyroid study. Parle J , Roberts L , Wilson S , Pattison H , Roalfe A , Haque MS , Heath C , Sheppard M , Franklyn J , Hobbs FD J Clin Endocrinol Metab. 2010 Aug;95(8):3623-32. Epub 2010 May 25. Subclinical hypothyroidism (SCH) and cognitive dysfunction are both common in the […]

Subclinical hypothyroidism and the risk of coronary heart disease and mortality. Rodondi N , den Elzen WP , Bauer DC , Cappola AR , Razvi S , Walsh JP , Asvold BO , Iervasi G , Imaizumi M , Collet TH , Bremner A , Maisonneuve P , Sgarbi JA , Khaw KT , Vanderpump […]

Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy. Fast S , Hegedüs L , Grupe P , Nielsen VE , Bluhme C , Bastholt L , Bonnema SJ J Clin Endocrinol Metab. 2010 Aug;95(8):3719-25. Epub 2010 Jun 2. Stimulation with recombinant human TSH (rhTSH) before […]

Iodine biokinetics and radioiodine exposure after recombinant human thyrotropin-assisted remnant ablation in comparison with thyroid hormone withdrawal. Taieb D , Sebag F , Farman-Ara B , Portal T , Baumstarck-Barrau K , Fortanier C , Bourrelly M , Mancini J , De Micco C , Auquier P , Conte-Devolx B , Henry JF , Mundler […]

Treatment with tyrosine kinase inhibitors for patients with differentiated thyroid cancer: the M. D. Anderson experience. Cabanillas ME , Waguespack SG , Bronstein Y , Williams MD , Feng L , Hernandez M , Lopez A , Sherman SI , Busaidy NL J Clin Endocrinol Metab. 2010 Jun;95(6):2588-95. Epub 2010 Apr 14. Cabanillas et al […]

TOPIC: Treatment of transient hypothyroxinemia of prematurity Title: Phase 1 trial of four thyroid hormone regimens for transient hypothyroxinemia in neonates of less than 28 weeks’ gestation . Authors: La Gamma EF, van Wassenaer AG, Ares S, Golumbek SG, Kok JH, Quero J, Hong T, Rahbar MH, Morreale de Escobar G, Fisher DA, & Paneth […]

TOPIC: TSH receptor Title: Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Authors: Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CT, Raaka BM, & Gershengorn MC . Reference: Proc. Natl. Acad. […]

TOPIC: A biologically inactive TRH due to a mutant TRH-receptor Title: A family with complete resistance to thyrotropin-releasing hormone Authors: Bonomi M, Busnelli M, Beck-Peccoz P, Constanzo D, Antonica F, & Dolci C. Reference: New England Journal of Medicine 360: 731-734, 2009 Summary Background Recessive resistance to the action of TRH is a rare disorder […]

TOPIC: The importance of pre-ablation RAI scans Title: The utility of radioiodine scans prior to I131 ablation in patients with well-differentiated thyroid cancer Authors: Van Nostrand D, Aiken M, Atkins F, Moreau S, Garcia C, Acio E, Burman K, & Wartofsky L. Reference: Thyroid 2009 March 13 [Epub ahead of print] Summary Background The utility […]

* Second of a new series of ‘Mini-Editorials’ in ‘Thyroid News’ While accounting for only 1% of solid malignancies, thyroid carcinoma is the most common malignancy of the endocrine system. The majority are patients with well-differentiated thyroid carcinoma of follicular cell origin who are cured with adequate surgical management and radioiodine therapy. However, some thyroid […]

TOPIC: A role for Th17 T cells in AITD Title: Increases of the Th1/Th2 cell ratio in severe Hashimoto’s disease and in the proportion of Th17 cells in intractable Graves’ disease. Authors: Nanba T , Watanabe M , Inoue N , & Iwatani Y . Reference: Thyroid 19: 495-501, 2009 Summary Background CD4+ T cells […]

TOPIC: Incidence of thyroid cancer in France (1998-2006) Title: Thyroid cancer: is the incidence rise abating? Authors: Sassolas G, Hafdi-Nejjari Z, Remontet L, Bossard N, Belot A, Berger-Dutrieux N, Decaussin-Petrucci M, Bournaud C, Peix zithromax online JL, Orgiazzi J, Borson-Chazot F, and the ‘Group of Pathologists’ of the Rhône-Alpes Region. Reference: European Journal of Endocrinology […]

TOPIC: TSH reference range increases with aging Title: Extreme longevity is associated with increased serum thyrotropin. Authors: Atzmon G, Barzilai N, Hollowell JG, Surks MI, & Gabriely I. Reference: Journal of Clinical Endocrinology & Metabolism 94: 1251-1254, 2009 Summary Context The TSH reference range, specifically the setting of the upper reference limit, is currently controversial. […]

TOPIC: S onographic appearance of cystic thyroid nodules Title: Partially cystic thyroid nodules on ultrasound: probability of malignancy and sonographic differentiation. Authors: Lee M-J, Kim E-K, Kwak JY, & Kim MJ. Reference: Thyroid 19: 341-346, 2009 Summary Background Thyroid nodules are very common and a large portion of them are mixed echoic, with both solid […]

TOPIC: Thyroid function in pregnancy Title: Cigarette smoking during pregnancy is associated with alterations in maternal and fetal thyroid function. Authors: Shields B, Hill A, Bilous M, Knight B, Hattersley AT, Bilous RW, & Vaidya B. Reference: Journal of Clinical Endocrinology & Metabolism 94: 570-574, 2009 Summary Background Studies in the general population have shown […]

TOPIC: Amiodarone-induced thyrotoxicosis Title: Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome . Authors: Yiu K-H, Jim M-H, Lee C-H, Yuen M, Mok M, Shea Y-F, Fan K, Tse H-F, & Chow W-H. Reference: Journal of Clinical Endocrinology and Metabolism 94: 109-114, 2009 Summary Background Whether the risk of long-term major adverse cardiovascular events […]

TOPIC: Predictors of relapse in pediatric Graves’ disease Title: Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment. Authors: Kaguelidou F, Alberti C, Castanet M, Guitteny M-A, Czernichow P, Léger J (the French childhood Graves’ disease study group) Reference: Journal of Clinical Endocrinology & Metabolism93: 3817–3826, 2008 There is debate about […]

TOPIC: Role of membrane transporters of thyroid hormone on their transfer into the brain Title: Expression of the thyroid hormone transporter MCT8 (SLC16A2) and AOTP14 (SLC01C1) at the blood-brain barrier. Authors: Roberts LM, Woodford K, Zhou M, Black DS, et al. Reference: Endocrinology 149: 6251-6261, 2008 Summary Background Thyroid hormones require transport across cell membranes […]

TOPIC: Use of Pendrin antibody measurement in AITD Title: Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. Authors: Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, et al. Reference: Journal of Clinical Endocrinology & Metabolism94: 442-448, 2009 Context Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux […]