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Rightward shift in serum TSH range in individuals with exceptional longevity

TOPIC: TSH reference range increases with aging Title: Extreme longevity is associated with increased serum thyrotropin. Authors: Atzmon G, Barzilai N, Hollowell JG, Surks MI, & Gabriely I. Reference: Journal of Clinical Endocrinology & Metabolism 94: 1251-1254, 2009 Summary Context The TSH reference range, specifically the setting of the upper reference limit, is currently controversial. […]

Cigarette smoking and pregnancy

TOPIC: Thyroid function in pregnancy Title: Cigarette smoking during pregnancy is associated with alterations in maternal and fetal thyroid function. Authors: Shields B, Hill A, Bilous M, Knight B, Hattersley AT, Bilous RW, & Vaidya B. Reference: Journal of Clinical Endocrinology & Metabolism 94: 570-574, 2009 Summary Background Studies in the general population have shown […]

Adverse cardiovascular events in AIT

TOPIC: Amiodarone-induced thyrotoxicosis Title: Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome . Authors: Yiu K-H, Jim M-H, Lee C-H, Yuen M, Mok M, Shea Y-F, Fan K, Tse H-F, & Chow W-H. Reference: Journal of Clinical Endocrinology and Metabolism 94: 109-114, 2009 Summary Background Whether the risk of long-term major adverse cardiovascular events […]

Graves disease in children

TOPIC: Predictors of relapse in pediatric Graves’ disease Title: Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment. Authors: Kaguelidou F, Alberti C, Castanet M, Guitteny M-A, Czernichow P, Léger J (the French childhood Graves’ disease study group) Reference: Journal of Clinical Endocrinology & Metabolism93: 3817–3826, 2008 There is debate about […]

Thyroid hormone transport into the brain

TOPIC: Role of membrane transporters of thyroid hormone on their transfer into the brain Title: Expression of the thyroid hormone transporter MCT8 (SLC16A2) and AOTP14 (SLC01C1) at the blood-brain barrier. Authors: Roberts LM, Woodford K, Zhou M, Black DS, et al. Reference: Endocrinology 149: 6251-6261, 2008 Summary Background Thyroid hormones require transport across cell membranes […]

Thyroid autoimmunity

TOPIC: Use of Pendrin antibody measurement in AITD Title: Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. Authors: Yoshida A, Hisatome I, Taniguchi S, Shirayoshi Y, et al. Reference: Journal of Clinical Endocrinology & Metabolism94: 442-448, 2009 Context Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux […]

Thyroxine treatment in pregnant women with hypothyroidism

TOPIC: Treatment of pregnant hypothyroid women Title: The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidism. Authors: Loh JA, Wartofsky L, Jonklaas J, & Burman KD. Reference: Thyroid 19 (3): 269-275, 2009 Summary Background In the United States, many women are on thyroid hormone replacement for hypothyroidism […]

Thyroxine monotherapy restores serum T3 levels

TOPIC: Thyroxine replacement therapy Title: Serum T3 levels in athyreotic individuals during thyroxine therapy. Authors: Jonklaas J, Davidson B, Bhagat S, & Soldin SJ. Reference: Journal of the American Medical Association 20: 769-777, 2008 Summary Background Some hypothyroid patients on thyroxine (LT4) therapy report a variety of symptoms including poor mood, lethargy, and cognitive impairment […]

Tg-Ab and differentiated thyroid cancer

TOPIC: Tg-Ab measurements for prediction of recurrence in thyroid cancer Title: The prevalence of transient change of serum thyroglobulin antibody levels is useful for prediction of clinical recurrence in thyroglobulin-negative patients with differentiated thyroid carcinoma Authors: Kim WG , Yoon JH, Kim WB , Kim TY , Kim EY , Kim JM , Ryu JS […]

High frequency of inadequate TH replacement therapy

TOPIC: Treatment of hypothyroid patients Title: High frequency of – and factors associated with – thyroid hormone over-replacement and under-replacement in men & women aged 65 and over. Authors: Somwaru LL, Arnold AM, Joshi N, Fried LP, & Cappola AR. Reference: Journal of Clinical Endocrinology & Metabolism (epub – ahead of print) January 6, 2009 […]

Role of thyroid hormone receptor in cancer

TOPIC: Thyroid hormone receptor Title: Thyroid hormone receptor alpha1 acts as a potent suppressor of tumor invasiveness and metastasis. Authors: Martinez-Iglesias O, Garcia-Silva S, Tenbaum SP, Regadera J, Larcher F, Paramio JM, Vennstrom B, & Aranda A. Reference: Cancer Research 69: 501-509, 2009 Summary Background Loss of thyroid hormone receptors (TR) is a common feature […]

Thyroid autoimmunity and iodine nutritional status

TOPIC: Thyroid autoimmunity in schoolchildren Title: Thyroid autoimmunity in schoolchildren in a long-standing iodine sufficient area: correlation with gender, pubertal stage and maternal autoimmunity. Authors: Kaloumenou I, Mastorakos G, Alevizaki M, Duntas LH, Mantzou E, Ladopoulos C, Antoniou A, Chiotis D, Papassotiriou I, Chrousos GP, & Dacou-Voutetakis C. Reference: Thyroid 18: 747-754, 2008 Summary Background […]

Thyroid development

TOPIC: Genes involved in early thyroid development Title: Expression of Islet1 in thyroid deve buy cheap kamagra lopment related to budding, migration, and fusion of primordia. Authors: Westerlund J, Andersson L, Carlsson T, Zoppoli P, Fagman H, & Nilsson M. Reference: Developmental Dynamics 237, 3820-3829, 2008 Summary Background The thyroid is populated by two endocrine […]

Thyroid autoimmunity

TOPIC: Thymus contribution to thyroid autoimmunity Title: Influx of recent thymic emigrants into autoimmune thyroid disease glands in humans. Authors: Armengol MP, Sabater L, Fernandez M, Ruiz M, Alonso M, Otero MJ, Martinez-Caceres E, Jaraquemada E, & Pujol-Borrell R. Reference: Clinical & Experimental Immunology 153: 338-350, 2008 Summary Background The aetiology of autoimmune thyroid disease […]

Thyroid autoimmunity & encephalopathy

TOPIC: Hashimoto’s encephalopathy Title: Hashimoto's encephalopathy: epidemiology, pathogenesis and management Authors: Mocellin R , Walterfang M , & Velakoulis D . Reference: CNS Drugs 21: 799-811, 2007 Summary Background Hashimoto's encephalopathy is a term used to describe an encephalopathy of presumed autoimmune origin characterised by high titres of antithyroid peroxidase antibodies. In a similar fashion […]

Thyroid cancer

TOPIC: Use and misuse of thyroid cancer cell lines Title: DNA profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and mis-identification. Authors: Schweppe RE, Kloppe JP, Korch C, Pugazhenthi U, Benezra M, Knauf JA, Fagin JA, Marlow L, Copland JA, Smallridge RC, & Haugen BR. Reference: Journal […]

Early postoperative serum Tg measurement

TOPIC: Prognostic value of early postoperative serum Tg measured without TSH stimulation in DTC Title: Thyroglobulin measurement before rhTSH-aided 131 I ablation in detecting metastases from differentiated thyroid carcinoma. Authors: Giovanella L, Ceriani L, Suriano S, Ghelfo A, & Maffioli M. Reference: Clinical Endocrinology 69, 659–663, 2008 Summary Context The practice of routinely treating DTC […]

Nodule Size and Cancer

TOPIC: FNA in Subcentimeter Thyroid Nodules Title: The Value of Fine-Needle Aspiration Biopsy in Subcentimeter Thyroid Nodules Authors: Berker D, Aydin Y, Ustun I, Gul K, Tutuncu Y, Isik S, Delibasi T, Guler S. Reference: Thyroid 2008; 18:603-608 Summary Background The need to perform fine-needle aspiration biopsy (FNAB) on subcentimeter thyroid nodules is less clear […]

Reducing the risks of bleeding with FNAB

TOPIC: Percutaneous thyroid biopsy Title: Bilateral thyroid hematomas after fine-needle aspiration causing acute airway obstruction. Authors: Hor T & Lahiri SW. Reference: Thyroid 18: 567-570, 2008 Summary Background Percutaneous fine-needle biopsy (FNB) of thyroid nodules has been universally accepted as the most economical, dependable, and easy evaluation of thyroid nodules. FNB provides the best triage […]

Diagnostic accuracy of ultrasound criteria for solid thyroid nodules

TOPIC: Ultrasound of thyroid nodules Title: Benign and malignant thyroid nodules: US differentiation – A multicenter retrospective study. Authors: Moon WJ, Jung SL, Lee JH, Na DG, Baek JH, Lee YH, Kim J, Kim HS, Byun JS, Lee DH; & the Thyroid Study Group, the Korean Society of Neuro- and Head and Neck Radiology. Reference: […]

Restoration of euthyroidism in hyper- and hypothyroid patients improves erectile dysfunction

TOPIC: High prevalence of erectile dysfunction in untreated hyper- and hypothyroid patients Title: Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat? Authors: Krassas GE, Tziomalos K, Papadopoulou F, Pontikides N, & Perros P. Reference: Journal of Clinical Endocrinology & Metabolism 93: 1815-1819, 2008 Summary Background Erectile dysfunction (ED) is […]

Follicular thyroid carcinoma: reproducibility of histo-pathological findings

TOPIC: Thyroid cancer Title: Inter-observer and intra-observer reproducibility in the histo-pathology of follicular thyroid carcinoma. Authors: Franc B, De La Salmoniere P, Lange F, Hoang C, Louvel A, De Roquancourt A, Vilde F, Hejblum G, Chevret S, & Chastang C. Reference: Human Pathology 34: 1092-1100, 2003 Summary Context Thyroid nodules are very common, and most […]

Endothelium-dependent vasodilation by rhTSH

TOPIC: Vascular effects of TSH Title: Enhancement of vascular endothelial function by recombinant human thyrotrophin. Authors: Napoli R, Biondi B, Guardasole V, D'Anna C, De Sena A, Pirozzi C, Terracciano D, Mazzarella C, Matarazzo M, & Sacca L. Reference: Journal of Clinical Endocrinology & Metabolism 93: 1959-1963, 2008 Summary Background The cardiovascular consequences of thyroid […]

Routine evaluation of thyroid nodules using calcitonin determination

TOPIC: Calcitonin measurement for thyroid nodules: is it cost-effective? Title: Calcitonin measurement in the evaluation of thyroid nodules in the United States: A cost-effectiveness and decision analysis. Authors: Cheung K, Roman SA, Wang TS, Walker HD, & Sosa JA. Reference: Journal of Clinical Endocrinology & Metabolism 93: 2173-2180, 2008 Summary Background European studies have shown […]