Thyroid Manager requires free registration
Login or Register

Category archives for Uncategorized

Permanent Hypothyroidism after PPT

High rate of persistent hypothyroidism in a large-scale prospective study of postpartum thyroiditis in southern Italy. Stagnaro-Green A , Schwartz A , Gismondi R , Tinelli A , Mangieri T , Negro R . J Clin Endocrinol Metab. 2011 ,96(3):652-7. Limited data exist concerning the hormonal status of women with PPT at the end of […]

Few Patients with Subclinical Hyperthyroidism Progress to Overt Hyperthyroidism over 7 yr

Vadiveloo T , Donnan PT , Cochrane L , Leese GP The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism. J Clin Endocrinol Metab. 2011 Jan;96(1):E1-8. Epub 2010 Oct 6. This study was to define the rates of progression from subclinical hyperthyroidism (SH) to frank hyperthyroidism and normal thyroid […]

Neonatal T4 Levels in Preterm Infants

Levels of neonatal thyroid hormone in preterm infants and neurodevelopmental outcome at 5 1/2 years: millennium cohort study. Delahunty C , Falconer S , Hume R , Jackson L , Midgley P , Mirfield M , Ogston S , Perra O , Simpson J , Watson J , Willatts P , Williams F ; Scottish […]

Management of Very Low Risk PTC

Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis. Zetoune T , Keutgen X , Buitrago D , Aldailami H , Shao H , Mazumdar M , Fahey TJ 3rd , Zarnegar R Ann Surg Oncol. 2010 Dec;17(12):3287-93. The effectiveness of prophylactic central neck dissection (pCND) in the treatment of patients […]

Relation of Stimulated Post Ablation Tg to Tumor Recurrence

Thyroid cancer recurrence in patients clinically free of disease with undetectable or very low serum thyroglobulin values. Kloos RT J Clin Endocrinol Metab. 2010 Dec;95(12):5241-8. Epub One hundred seven patients had initial thyroid cancer surgery and subsequent remnant radioiodine ablation. Patients underwent recombinant human TSH (rhTSH)-mediated diagnostic whole-body scan and rhTSH-stimulated thyroglobulin (Tg) measurement before […]

An Extensive Review of the Role of Selenium in Thyroid Homeostasis

Selenium and the thyroid: a close-knit connection. Duntas LH J Clin Endocrinol Metab. 2010 Dec;95(12):5180-8. Epub 2010 Sep 1. The recent recognition that the essential trace element selenium is incorporated as selenocysteine in all three deiodinases has decisively confirmed the clear-cut link between selenium and thyroid function. It has additionally been established that the thyroid […]

Making the Case for RAI Treatment of Intra-thoracic Goiter

Approach to management of the patient with primary or secondary intrathoracic goiter. Hegedüs L , Bonnema SJ J Clin Endocrinol Metab. 2010 Dec;95(12):5155-62. Intrathoracic (substernal) goiter, depending on definition, is seen in up to 45% of all patients operated for goiter. It can either be primary (ectopic thyroid tissue detached from a cervical thyroid mass), […]

Correlation of BRAF V600E mutations and tumor invaseness in papillary thyroid carcinoma

JCEM 2010, 95(9):4197-4205 Basolo et al Evaluation of the degree of neoplastic infiltration beyond the thyroid capsule remains a unique parameter that can be evaluated by histopathological examination to label a papillary thyroid carcinoma (PTC) of 20 mm or less in size as a pT1 or pT3 tumor. We correlated the BRAF V600E mutation with […]

A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: The Birmingham Elderly Thyroid study

The Birmingham Elderly Thyroid study. Parle J , Roberts L , Wilson S , Pattison H , Roalfe A , Haque MS , Heath C , Sheppard M , Franklyn J , Hobbs FD J Clin Endocrinol Metab. 2010 Aug;95(8):3623-32. Epub 2010 May 25. Subclinical hypothyroidism (SCH) and cognitive dysfunction are both common in the […]

More on Possible Adverse Effects of Subclinical Hypothyroidism

Subclinical hypothyroidism and the risk of coronary heart disease and mortality. Rodondi N , den Elzen WP , Bauer DC , Cappola AR , Razvi S , Walsh JP , Asvold BO , Iervasi G , Imaizumi M , Collet TH , Bremner A , Maisonneuve P , Sgarbi JA , Khaw KT , Vanderpump […]

Treatment of MNG with RAI

Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy. Fast S , Hegedüs L , Grupe P , Nielsen VE , Bluhme C , Bastholt L , Bonnema SJ J Clin Endocrinol Metab. 2010 Aug;95(8):3719-25. Epub 2010 Jun 2. Stimulation with recombinant human TSH (rhTSH) before […]

Radiation Exposure During Remnant Ablation

Iodine biokinetics and radioiodine exposure after recombinant human thyrotropin-assisted remnant ablation in comparison with thyroid hormone withdrawal. Taieb D , Sebag F , Farman-Ara B , Portal T , Baumstarck-Barrau K , Fortanier C , Bourrelly M , Mancini J , De Micco C , Auquier P , Conte-Devolx B , Henry JF , Mundler […]

More Reports on Tyrosine kinase Ihibitors in Thyroid Cancer

Treatment with tyrosine kinase inhibitors for patients with differentiated thyroid cancer: the M. D. Anderson experience. Cabanillas ME , Waguespack SG , Bronstein Y , Williams MD , Feng L , Hernandez M , Lopez A , Sherman SI , Busaidy NL J Clin Endocrinol Metab. 2010 Jun;95(6):2588-95. Epub 2010 Apr 14. Cabanillas et al […]

Treatment of extremely low gestational age neonates (ELGANS) with thyroid hormone

TOPIC: Treatment of transient hypothyroxinemia of prematurity Title: Phase 1 trial of four thyroid hormone regimens for transient hypothyroxinemia in neonates of less than 28 weeks’ gestation . Authors: La Gamma EF, van Wassenaer AG, Ares S, Golumbek SG, Kok JH, Quero J, Hong T, Rahbar MH, Morreale de Escobar G, Fisher DA, & Paneth […]

Development of orally active agonists of the TSH receptor

TOPIC: TSH receptor Title: Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Authors: Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CT, Raaka BM, & Gershengorn MC . Reference: Proc. Natl. Acad. […]

Complete resistance to TRH in a family

TOPIC: A biologically inactive TRH due to a mutant TRH-receptor Title: A family with complete resistance to thyrotropin-releasing hormone Authors: Bonomi M, Busnelli M, Beck-Peccoz P, Constanzo D, Antonica F, & Dolci C. Reference: New England Journal of Medicine 360: 731-734, 2009 Summary Background Recessive resistance to the action of TRH is a rare disorder […]

Management of well-differentiated thyroid cancer prior to radioiodine ablation

TOPIC: The importance of pre-ablation RAI scans Title: The utility of radioiodine scans prior to I131 ablation in patients with well-differentiated thyroid cancer Authors: Van Nostrand D, Aiken M, Atkins F, Moreau S, Garcia C, Acio E, Burman K, & Wartofsky L. Reference: Thyroid 2009 March 13 [Epub ahead of print] Summary Background The utility […]

Title: Side effects of tyrosine kinase inhibitors

* Second of a new series of ‘Mini-Editorials’ in ‘Thyroid News’ While accounting for only 1% of solid malignancies, thyroid carcinoma is the most common malignancy of the endocrine system. The majority are patients with well-differentiated thyroid carcinoma of follicular cell origin who are cured with adequate surgical management and radioiodine therapy. However, some thyroid […]

T helper cell subsets in autoimmune thyroid disease

TOPIC: A role for Th17 T cells in AITD Title: Increases of the Th1/Th2 cell ratio in severe Hashimoto’s disease and in the proportion of Th17 cells in intractable Graves’ disease. Authors: Nanba T , Watanabe M , Inoue N , & Iwatani Y . Reference: Thyroid 19: 495-501, 2009 Summary Background CD4+ T cells […]

Changes in thyroid cancer incidence are mainly related to better detection sensitivity of microcarcinomas

TOPIC: Incidence of thyroid cancer in France (1998-2006) Title: Thyroid cancer: is the incidence rise abating? Authors: Sassolas G, Hafdi-Nejjari Z, Remontet L, Bossard N, Belot A, Berger-Dutrieux N, Decaussin-Petrucci M, Bournaud C, Peix zithromax online JL, Orgiazzi J, Borson-Chazot F, and the ‘Group of Pathologists’ of the Rhône-Alpes Region. Reference: European Journal of Endocrinology […]